Eph receptor A7/EPHA7 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Eph receptor A7 (EPHA7) also known by its synonym EHK3 is part of the Eph family of receptor tyrosine kinases. It has a molecular mass of approximately 130 kDa. EPHA7 is mainly expressed in the brain but also shows presence in other tissues such as lymphoid tissues. This receptor plays a central role in the repulsion signals guiding cell migration and positioning through its interaction with ephrin ligands.

Biological function summary

EPHA7 functions in the organization of the nervous system and immune response regulation. It operates in the context of a receptor-ligand complex that involves ephrin-A ligands which facilitates cellular communication and positioning. By participating in these processes EPHA7 helps shape neural network formation and modulates immune cell interactions. These biological roles highlight its importance in maintaining tissue architecture.

Pathways

EPHA7 participates in key signaling pathways such as the ephrin receptor signaling pathway and the MAPK signaling cascade. This receptor interacts with proteins from these pathways including ephrin-A5 and MAPK influencing processes like cell adhesion and migration. These pathways establish EPHA7 as an important player in developmental processes and contribute to its role in tissue maintenance and repair.

EPHA7 shows connections with cancer and neurodevelopmental disorders. In cancer alterations in EPHA7 expression and function have been linked to tumor progression and metastasis often in conjunction with proteins such as ephrin-A5. Neurodevelopmental disorders also relate to EPHA7 as disruptions in its signaling can impact brain development potentially involving interactions with other Eph receptors. These connections highlight the receptor's importance in disease mechanisms making it a valuable target for therapeutic exploration.