GRB10 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Growth Factor Receptor-Bound Protein 10 often referred to as GRB10 is an adaptor protein with a mass of approximately 66 kDa. This protein interacts with various receptor tyrosine kinases and other intracellular signaling molecules. GRB10 is expressed in many tissues but it shows higher expression in the brain muscle and liver. It plays a significant role as a modulator in cellular processes that involve signal transduction.

Biological function summary

GRB10 interacts with receptor tyrosine kinases such as the insulin receptor and engages in regulating the insulin signaling pathway. It acts as part of a complex that influences cell growth and metabolism. GRB10 binds Via its SH2 domain to activated receptors such as IGF-1R altering downstream signaling and having an impact on growth and metabolic processes.

Pathways

GRB10 is integral to the PI3K-AKT signaling pathway and the mTOR pathway. It negatively regulates these pathways by binding to receptors and altering downstream effects. GRB10 interacts with proteins such as IRS1 and mTORC1 affecting how cells respond to insulin and growth factors. Through these interactions it contributes to cellular metabolism and growth regulation.

Studies show that GRB10 has connections to conditions like cancer and type 2 diabetes. Alterations in GRB10's function or expression can lead to abnormal cellular signaling contributing to oncogenesis due to disrupted growth signals. In type 2 diabetes GRB10 affects insulin signaling pathways which is related to insulin resistance. These disorders show interconnection with proteins like IRS1 where GRB10 modulates pathways influencing disease states.