Hep G2 whole cell lysate

Cell line: HepG2 (Human hepatocellular carcinoma).

Hep G2 whole-cell extract was prepared from cell cultures of the human hepatocellular liver carcinoma HepG2 cell line. These cells are epithelial in morphology and can be induced to exhibit polarization under appropriate culture conditions.

HepG2 cells are most commonly used for studies of hepatocyte function and this HepG2 whole cell lysate is specifically recommended for studies related to:

- human liver diseases, cancers and drug therapies

- HBV etiology

- signaling pathways

- apoptosis

Because of their ability to differentiate into polarized epithelium, these cells are routinely utilized to investigate intracellular protein trafficking, particularly in relation to human liver diseases. HepG2 is the most commonly used cell line in studies pertaining to the regulation of hepatic protein synthesis, particularly the synthesis of acute phase proteins after the onset of a systemic inflammatory response.

In addition, these cells are important for studies related to liver metabolism, liver cancers, liver regeneration, liver cytotoxicity, apoptosis and as a model for hepatitis B virus (HBV) viral etiology.