hHR23b overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The human Rad23 homolog B (hHR23b) also known as RAD23B is a protein involved in DNA repair mechanisms. It weighs approximately 43 kDa and is expressed in several tissues including the skin lungs and kidneys. Mechanically hHR23b is important in the process of nucleotide excision repair (NER) where it helps recognize and repair UV-induced DNA damage. hHR23b interacts with other proteins to facilitate the repair process by removing bulky DNA lesions.

Biological function summary

HHR23b plays an important role in maintaining genomic stability. It forms a complex with xeroderma pigmentosum group C (XPC) protein which is instrumental in identifying DNA damage. This complex functions as the initial damage sensor in the NER pathway. By participating in this multiprotein complex hHR23b facilitates the recruitment of other DNA repair factors ultimately ensuring the fidelity of DNA replication.

Pathways

HHR23b is instrumental in NER and proteasome degradation. In the NER pathway it functions alongside the XPC protein to initiate the repair of damaged DNA. Through its interaction with the proteasome system hHR23b is also involved in the ubiquitin-proteasome pathway which regulates protein degradation. This dual involvement in pathways links hHR23b to both DNA repair and the regulation of protein turnover.

HHR23b is associated with cancer and neurodegenerative conditions. The malfunction or altered expression of hHR23b can lead to impaired DNA repair promoting oncogenic transformations and cancer progression specifically through its association with the XPC protein. Furthermore its role in protein degradation connects hHR23b to neurodegenerative diseases like Parkinson's where protein accumulation contributes to disease progression. Understanding these connections helps in devising therapeutic strategies targeting hHR23b and its related pathways.