Human AES (Amino-terminal enhancer of split) knockout HCT116 cell lysate

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Amino-terminal enhancer of split commonly known as AES is a protein with a molecular mass of approximately 22 kDa. It functions as a transcriptional repressor and is involved in controlling gene expression by interacting with DNA. AES is expressed in various tissues including the brain heart and liver indicating its broad role in different biological processes. Its ability to inhibit specific gene expression highlights its involvement in intricate regulatory mechanisms. Researchers also recognize the protein by other names such as enhancer protein and protein enhancer.

Biological function summary

AES interacts with corepressor proteins to form a complex that modulates transcriptional activity. This complex involvement is critical for developmental processes and cell differentiation affecting how cells acquire specialized functions. Through these interactions AES influences the activities of target genes that are essential for organismal development. The presence of AES in significant developmental pathways highlights its regulatory function in cellular mechanisms.

Pathways

AES plays an important role in the Notch signaling and Wnt signaling pathways both integral to cellular differentiation and proliferation. AES specifically interacts with components of these pathways acting to modulate their signaling outcomes. In the Notch signaling pathway AES functions by repressing gene expression therefore maintaining proper cellular balance. Similarly within the Wnt signaling pathway AES interacts with other pathway proteins such as TCF7L2 to adjust gene transcription ensuring normal cellular development and proliferation.

Associated diseases and disorders

AES has connections to certain types of cancer and neurodevelopmental disorders. Aberrant expression or mutation of AES can lead to disruptions in normal signaling contributing to pathological conditions. In cancer the dysregulation of the Notch signaling pathway where AES plays an important regulatory role is often associated with tumorigenesis. Additionally AES interactions with other proteins like TCF7L2 in Wnt signaling pathways may be implicated in colorectal cancer progression. In neurodevelopmental disorders alterations in the AES function can affect brain development potentially leading to conditions like autism spectrum disorders.