Human ANKRD52 (ANR52) knockout HEK-293T cell lysate
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ANKRD52 KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, Homozygous: 14 bp deletion in exon 4.
View Alternative Names
6430544C07, ANR52_HUMAN, Ankyrin repeat domain-containing protein 52, G431002C21Rik, PP6-ARS-C, RGD1307124, Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C, Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C, ankrd52
- Sanger seq
Unknown
Sanger Sequencing - Human ANKRD52 (ANR52) knockout HEK-293T cell lysate (AB263088)
Homozygous : 14 bp deletion in exon 4
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Zygosity
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The function of ANR52 is to partake in cellular communication and signaling. ANR52 is involved as a part of a larger protein complex which aids in the localization and stabilization of proteins at the cell membrane. It interacts with key signaling molecules influencing pathways that regulate cellular processes such as proliferation and apoptosis. The role of ANR52 in maintaining cellular homeostasis is essential for proper cell function and health.
Pathways
The activities of ANR52 focus on regulation within the NF-kB and MAPK signaling pathways. These pathways oversee a variety of cellular responses including inflammation and stress responses. ANR52 interacts with proteins such as IKK and Raf forming connections that modulate the pathway's activity. By doing so ANR52 assists cells in adapting to environmental stimuli and maintaining physiological balance.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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