Human ARL6IP1 knockout HEK-293T cell lysate
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ARL6IP1 KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 7 bp deletion in exon1.
View Alternative Names
ADP ribosylation factor like 6 interacting protein, ADP-ribosylation factor-like protein 6-interacting protein 1, AR6P1_HUMAN, ARL-6-interacting protein 1, ARL6IP, ARMER, Arl6ip1, KIAA0069
- Sanger seq
Unknown
Sanger Sequencing - Human ARL6IP1 knockout HEK-293T cell lysate (AB258313)
Homozygous : 7 bp deletion in exon1
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ARL6IP1 acts as a modulator of intracellular membrane structures and dynamics. It is not typically understood as part of a larger macromolecular complex but rather operates through interactions with membrane components. The protein assists in membrane curvature processes and is important in maintaining cellular compartmentalization.
Pathways
Several research studies implicate ARL6IP1 in the regulation of the vesicular transport pathway. It interacts with proteins involved in the Golgi to endoplasmic reticulum transport like the COPI machinery. ARL6IP1 also associates with lipid metabolism pathways through its regulatory roles particularly touching on relationships with proteins such as ARF1 that are active in endomembrane system organization.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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