Human ARL8B knockout HeLa cell lysate

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ARL8B also known as ADP-ribosylation factor-like protein 8B is a small GTPase with an approximate molecular mass of 22 kDa. It mainly localizes to the lysosomal membrane. This protein plays an important role in the regulation of intracellular trafficking and lysosome positioning. ARL8B is expressed across many tissues suggesting its involvement in broad cellular functions.

Biological function summary

ARL8B helps manage the proper function of lysosomes by facilitating their movement and fusion with other cellular compartments. It forms a complex with other proteins such as PLEKHM2 and HOPS which are necessary for tethering events during lysosomal trafficking. This protein contributes to cellular processes such as autophagy and antigen presentation influencing the cell's ability to maintain homeostasis and effectively respond to external stimuli.

Pathways

ARL8B participates in the autophagy pathway and plays a part in the lysosome-related processes. It works closely with proteins like the kinesin motor proteins which drive the movement of lysosomes along microtubules. Through these interactions ARL8B coordinates with other autophagy-related proteins to ensure efficient degradation of cellular debris and recycling of components which are important for cellular health and function.

Associated diseases and disorders

ARL8B has links to neurodegenerative diseases and immune system dysfunctions. Dysregulation of lysosomal positioning and movement caused by abnormal ARL8B function can lead to conditions such as Charcot-Marie-Tooth disease and impaired immune responses. Furthermore ARL8B interacts with proteins like Rab7a which can have implications in disease pathways emphasizing its significant role in maintaining cellular balance.