Human C19orf24 knockout HEK-293T cell lysate
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FAM174C KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, Insertion of the selection cassette in exon1.
View Alternative Names
C19orf24, CS024_HUMAN, Chromosome 19 open reading frame 24, FLJ20640, Hypothetical protein LOC55009, Uncharacterized membrane protein C19orf24
- Sanger seq
Unknown
Sanger Sequencing - Human C19orf24 knockout HEK-293T cell lysate (AB263122)
Homozygous : Insertion of the selection cassette in exon1
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein encoded by C19orf24 has interactions that suggest roles in cellular and molecular processes. It is not part of a known larger protein complex. Evidence suggests involvement in cytokine signaling and response making it an interesting target for studies focused on immune response and inflammation. The identification of specific binding partners remains an ongoing area of research as understanding these interactions could clarify its biological roles further.
Pathways
Multiple cytokine mediated signaling pathways involve C19orf24 especially in relation to immune system regulation. It contributes to key pathways like the IL-6 signaling which is important for inflammatory response and possibly interacts with related proteins such as STAT3 a well-known signaling molecule in immune reactions. Continued mapping of these pathways will help elucidate the broader impact of C19orf24 on cellular functions.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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