Human COA1 (C7orf44) knockout HEK-293T cell lysate
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COA1 KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 3 and 7 bp deletion in exon 3.
View Alternative Names
Chromosome 7 open reading frame 44, FLJ10803, Hypothetical protein LOC55744, Uncharacterized protein C7orf44
- Sanger seq
Unknown
Sanger Sequencing - Human COA1 (C7orf44) knockout HEK-293T cell lysate (AB263158)
Allele-2 : 1 bp insertion in exon 3
- Sanger seq
Unknown
Sanger Sequencing - Human COA1 (C7orf44) knockout HEK-293T cell lysate (AB263158)
Allele-1 : 7 bp deletion in exon 3
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein encoded by C7orf44 has been associated with cellular growth and maintenance functions. It is not yet confirmed as part of any known multiprotein complexes. Current research suggests that C7orf44 can intertwine with cellular pathways impacting growth regulation emphasizing its role in sustaining cellular environments. The broad expression hints at general cell function support rather than specialized organ-specific tasks.
Pathways
The protein's involvement in cellular growth ties it to important biological pathways such as signaling pathways regulating cellular proliferation and apoptosis. Although specific partners remain to be definitively identified the protein may interact with other regulatory proteins in these pathways. This positions C7orf44 as an intriguing target for further study in relation to cellular signaling mechanisms particularly with proteins influencing similar pathways.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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