Human EI24 knockout HeLa cell lysate

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

EI24 also known as PIG8 is an apoptosis-inducing factor which has a molecular weight of approximately 24 kDa. It functions mechanically by inducing programmed cell death and is involved in the p53 pathway which is associated with tumor suppression. EI24 is widely expressed in various tissues with higher expression observed in the thymus lymph nodes and spleen.

Biological function summary

The activity of EI24 is significant in regulating apoptosis. It contributes to cellular homeostasis by facilitating the elimination of damaged or unneeded cells. EI24 does not operate as part of any known large protein complexes but it interacts with proteins related to the cell cycle and apoptosis regulation. By promoting apoptosis EI24 helps maintain normal cellular functions and prevents the accumulation of defective cells.

Pathways

Several important biological activities involve EI24. It plays a role in the p53-mediated apoptotic pathway which is critical for responding to DNA damage and other cellular stresses. In this pathway EI24 interacts with the tumor suppressor protein p53 promoting cell death in response to DNA damage. EI24 also associates with Bcl-2 family proteins which influence the apoptotic process. This association suggests a role for EI24 in promoting apoptosis through mitochondrial pathways.

Associated diseases and disorders

EI24 is linked to certain types of cancer including breast cancer and lymphomas. Altered expression or mutations in the EI24 gene can contribute to tumorigenesis and cancer progression. Studies show that the loss of EI24 function interacts with p53 mutations influencing tumor development and resistance to apoptosis. The role of EI24 in cancer highlights its potential as a target for therapeutic interventions aiming to restore the apoptotic pathways in cancer cells.