Human FAM129B knockout HEK-293T cell lysate
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NIBAN2 KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, Homozygous: 19 bp deletion in exon 2.
View Alternative Names
C9orf88, DKFZP434H0820, FLJ13518, FLJ22151, FLJ22298, Meg-3, NIBL1_HUMAN, Niban-like protein 1, OC58, OTTHUMP00000022187, OTTHUMP00000022188, Protein FAM129B, bA356B19.6, chromosome 9 open reading frame 88, family with sequence similarity 129, member B, hypothetical protein LOC64855
- Sanger seq
Unknown
Sanger Sequencing - Human FAM129B knockout HEK-293T cell lysate (AB258866)
Homozygous : 19 bp deletion in exon 2
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
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It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Zygosity
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
FAM129B engages in apoptosis modulation and cell survival playing a significant part in cellular stress response. The protein often partners with other components to form complexes that influence intracellular signaling pathways. Specifically by interacting with protein tyrosine phosphatases it affects the delicate balance between survival and programmed cell death providing cells the ability to adapt to fluctuating environmental challenges.
Pathways
FAM129B integrates into the MAPK and PI3K/AKT signaling pathways which are vital for regulating cell survival proliferation and differentiation. Within these pathways FAM129B associates with proteins like AKT and ERK that mediate its impact on cell survival signaling. Its involvement in these pathways suggests a regulatory role in cellular responses to external stimuli contributing to the maintenance of homeostasis.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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