Human HOXA9 knockout HEK-293 cell lysate
Be the first to review this product! Submit a review
|
(0 Publication)
HOXA9 KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, Homozygous: 103 bp deletion in exon 1.
View Alternative Names
ABD-B, Abd-B, drosophila, homolog of, D6a9, HOX1, HOXA9/MSI2 fusion gene, included, HOXA9/NUP98 fusion gene, included, HXA9_HUMAN, Homeobox 1G, Homeobox A9, Homeobox protein Hox-1.7, Homeobox protein Hox-1G, Homeobox protein Hox-A9, Homeodomain protein HOXA9, Hox-1.7, Hox-1.7, mouse, homolog of, Hox1G, Hox1r5, MGC1934
- Sanger seq
Lab
Sanger Sequencing - Human HOXA9 knockout HEK-293 cell lysate (AB280112)
103 bp deletion in exon 1
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Zygosity
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HOXA9 controls the transition and lineage commitment of hematopoietic stem cells. The protein often interacts as part of a transcriptional complex involving other HOX family proteins to maintain proper gene expression balance. This regulatory function is essential for normal gene expression patterns needed in stem cell differentiation and organ development processes.
Pathways
HOXA9 plays significant roles in the hematopoietic cell lineage and the retinoic acid signaling pathway. Through these pathways it collaborates with other HOX proteins like HOXB4 to maintain stem cell properties and influence the differentiation process. These interactions facilitate the production of necessary blood cell types and ensure effective response mechanisms to various developmental cues.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
![Immunoprecipitation - Anti-HOXA9 antibody [EPR3655(2)] (AB140631)](https://content.abcam.com/products/images/hoxa9-antibody-epr36552-ab140631--immunoprecipitation-img408403.jpg)
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com