Human LRRC41 knockout HeLa cell lysate
Be the first to review this product! Submit a review
|
(0 Publication)
LRRC41 KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon1.
View Alternative Names
Leucine rich repeat containing 41, Leucine rich repeat containing protein 41, MUF1, PP7759, elongin BC interacting leucine rich repeat protein
- Sanger seq
Unknown
Sanger Sequencing - Human LRRC41 knockout HeLa cell lysate (AB263246)
Homozygous : 1 bp deletion in exon1
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LRRC41 plays an essential role in cellular signaling and regulation. It may function as part of larger protein complexes facilitating various regulatory functions. The protein contributes significantly to the regulation of cell cycle and apoptosis among other cellular processes. Its interactions within the cell modulate the signaling pathways that control these vital processes enabling the cell to respond to different stimuli effectively.
Pathways
The LRRC41 protein is involved in the modulation of the MAPK signaling pathway. This pathway is important for transducing extracellular signals into intracellular responses and it is important in cell growth and differentiation. LRRC41 interacts with proteins within this pathway such as RAF1 and MEK to influence signal transduction events. Its involvement in these pathways highlights its role in maintaining cellular homeostasis and responding to environmental changes.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com