Human MEOX1 (MOX1) knockout HeLa cell lysate
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MEOX1 KO cell lysate available now. KO validated. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 14 bp deletion in exon1.
View Alternative Names
Homeobox protein MOX-1, MEOX1_HUMAN, MOX 1, Mesenchyme homeo box 1
- Sanger seq
Unknown
Sanger Sequencing - Human MEOX1 (MOX1) knockout HeLa cell lysate (AB258046)
Allele-1 : 14 bp deletion in exon1
- Sanger seq
Unknown
Sanger Sequencing - Human MEOX1 (MOX1) knockout HeLa cell lysate (AB258046)
Allele-2 : 14 bp deletion in exon1
Reactivity data
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MEOX1 plays a role in segment identity and myogenesis. It helps direct the formation of somites which are essential precursor structures for the vertebral column and skeletal muscles. MEOX1 does not function alone; it often interacts with other homeobox proteins forming complexes that finely control the transcription of genes essential for development. This interaction ensures proper segment patterning and muscle differentiation important for normal embryonic development.
Pathways
MEOX1 has an essential place in the Wnt signaling and Notch signaling pathways. These pathways are significant during embryogenesis for the regulation of development and cell fate decisions. In these pathways MEOX1 interacts with proteins like TCF/LEF family members and the Notch intracellular domain. The integration of MEOX1 into these pathways underpins its ability to influence various developmental processes indicating its extensive regulatory potential.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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