Human MOK knockout HeLa cell lysate

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOK protein kinase also known as RAGE or MAPK15 belongs to the MAP kinase family and shows a molecular mass of approximately 65 kDa. This protein undergoes expression mainly within testis and prostate tissues but presence occurs in smaller amounts in other tissues like kidney and lung. MOK carries out functions by phosphorylating various substrates impacting signaling pathways that regulate cellular outcomes. As part of the regulatory protein kinase family MOK shows interactions with multiple downstream elements demonstrating its versatile role in cellular systems.

Biological function summary

MOK protein kinase influences processes like cellular differentiation proliferation and apoptosis. Although not specifically part of a larger complex it interacts with other protein kinases indicating a role in signal transduction. MOK contributes to the fine-tuning of cellular responses impacting how cells react to different stimuli by modulating key regulatory proteins. Through its effects on substrate proteins MOK influences critical cellular activities highlighting its importance in maintaining cellular functions.

Pathways

MOK protein kinase participates in the MAPK signaling pathway a significant influencer of cellular responses to external stimuli. Through this pathway MOK interacts with proteins like ERK and JNK modulating cellular responses to diverse stressors. Another key pathway involving MOK includes the cell cycle regulation pathway providing input towards decision making between cell proliferation and cell cycle arrest. This protein's involvement in these pathways indicates its integrated role in maintaining cellular homeostasis and responding to changes in the environment.

MOK protein kinase associates with several conditions including cancer and neurodegenerative disorders. For example abnormal MOK signaling appears in certain prostate cancers linking MOK to oncogenic processes potentially through interactions with proteins like p53. In neurodegenerative disorders altered MOK expression affects neuronal survival pathways connecting it to damage seen in diseases such as Alzheimer's. Understanding MOK's function and interactions with proteins relevant to these diseases brings insight into its therapeutic potential.