Human PANK4 (Pantothenate kinase 4) knockout HEK-293T cell lysate

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Pantothenate kinase 4 also known as PANK4 plays an important role in the initial step of the coenzyme A (CoA) biosynthesis pathway. This enzyme catalyzes the phosphorylation of pantothenate (vitamin B5) to produce 4'-phosphopantothenate a critical step in the pathway. PANK4 has a mass of approximately 86 kDa. Researchers have observed its expression in various tissues including the liver which hints at its potential regulatory functions in metabolic processes across different biological systems.

Biological function summary

PANK4 participates in the regulation of CoA levels within cells impacting fatty acid metabolism and energy production. It does not exist as part of a larger protein complex but works in a network of enzymes involved in metabolic regulation. By modulating CoA availability PANK4 influences the synthesis and degradation of fatty acids playing a central role in maintaining cellular energy balance. This activity is especially important in tissues with high metabolic rates such as the liver.

Pathways

PANK4 is an important participant in the CoA biosynthesis pathway and impacts the fatty acid oxidation pathway. It functions collaboratively with other enzymes such as acyl-CoA dehydrogenases which are involved in the breakdown of fatty acids for energy production. The regulation of these pathways by PANK4 is significant for maintaining efficient energy metabolism. Its activity influences how the body stores and uses energy particularly during periods of fasting and high energy demand.

Associated diseases and disorders

PANK4 has a connection to metabolic disorders and neurodegenerative diseases. Its role in CoA biosynthesis links it to conditions such as type 2 diabetes where improper fatty acid metabolism occurs. Additionally disruptions in CoA balance may relate PANK4 to neurodegenerative diseases like Huntington’s disease as energy dysregulation impacts neuron function. The study of PANK4 in these contexts sheds light on its potential as a therapeutic target for managing energy-related health issues.