Human PTGER3 knockout HeLa cell lysate

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PTGER3 protein also known as the prostaglandin E2 receptor EP3 subtype is a G-protein coupled receptor (GPCR) with a molecular weight of approximately 53 kDa. This receptor binds prostaglandin E2 (PGE2) and modulates various physiological responses by activating different second messenger systems. PTGER3 exhibits diverse expression patterns being present in tissues such as the smooth muscle kidney uterus neural tissues and certain immune cells. Its expression in various tissues suggests its involvement in multiple functions that rely on PGE2 signaling.

Biological function summary

PTGER3 involves itself in mediating the effects of prostaglandin E2 through the inhibition of adenylate cyclase and the modulation of intracellular calcium levels. It does not operate as part of a larger protein complex but functions independently as a receptor. This receptor's activity influences processes such as smooth muscle contraction regulation of body temperature and modulation of hormone release. The variation in signaling allows PTGER3 to have a broad impact on physiological processes adapting its functions based on tissue and cellular context.

Pathways

PTGER3 is part of the prostaglandin signaling pathway and participates in cAMP signaling. It interacts with G-proteins that act as intermediates to modulate adenylate cyclase activity and control cyclic AMP production. The receptor acts in a network with other prostaglandin receptors such as PTGER1 PTGER2 and PTGER4 coordinating responses to PGE2 by either amplifying or opposing their effects depending on the cellular environment. Such interactions position PTGER3 at the junction of pathways critical for homeostatic control and adaptive responses.

PTGER3 has connections to several conditions including inflammatory diseases and hypertension. Inflammatory diseases such as rheumatoid arthritis show altered PGE2 signaling pathways where PTGER3 plays a role in mediating inflammation and immune responses. Its activity is also implicated in regulating blood pressure by influencing vascular smooth muscle contraction. Additionally its function intersects with proteins like COX-2 which is involved in PGE2 biosynthesis indicating a broader role in maintaining homeostasis within disease contexts.