SERBP1 KO cell lysate available now. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 23 bp deletion in exon 1 and 29 bp deletion in exon 1.
HEK-293T
Human
Kidney
Sanger Sequencing
Knockout achieved by using CRISPR/Cas9, 23 bp deletion in exon 1 and 29 bp deletion in exon 1.
CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, DKFZp564M2423, FLJ90489, HABP4L, PAI 1 mRNA binding protein, PAI-RBP1, PAI1 RNA-binding protein 1, PAIRB_HUMAN, Plasminogen activator inhibitor 1 RNA-binding protein, SERPINE1 mRNA-binding protein 1
SERBP1 KO cell lysate available now. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 23 bp deletion in exon 1 and 29 bp deletion in exon 1.
HEK-293T
Human
Kidney
Sanger Sequencing
Knockout achieved by using CRISPR/Cas9, 23 bp deletion in exon 1 and 29 bp deletion in exon 1.
SERBP1
Knockout
CRISPR technology
Sanger Sequencing
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
EU: 2 US: 2
Adherent
Female
Ambient - Can Ship with Ice
-20°C
-20°C
Knockout cell lysate achieved by CRISPR/Cas9.
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It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
This supplementary information is collated from multiple sources and compiled automatically.
SERBP1 also known as SCR3 is a protein weighing approximately 46 kDa. This protein interacts with specific mRNA sequences acting as a binding protein that influences mRNA stability and modulates the translation process. SERBP1 is widely expressed in various tissues notably in the liver and placenta where it plays a role in cellular activities related to protein synthesis.
Activities performed by SERBP1 involve regulation of mRNA turnover and translation impacting critical cellular functions. SERBP1 forms part of the ribonucleoprotein complexes which bind to mRNA and stabilize it therefore influencing gene expression. Through these interactions it has a significant impact on the control of translation processes within the cell alongside other regulatory proteins.
SERBP1 participates in mRNA surveillance and regulation pathways. This protein interacts with key translation pathways contributing to processes that ensure only properly processed mRNA is translated into proteins. SERBP1's role in these pathways may involve interactions with proteins like eIF4E which also plays a part in translation initiation thereby maintaining cellular homeostasis and efficiency in protein production.
Changes in SERBP1 expression or function can relate to cancer and liver disease. In such conditions aberrant regulation of mRNA stability may occur leading to dysregulated protein synthesis that contributes to pathogenesis. SERBP1 is connected to proteins such as c-Myc in cancer where it may play a role in the overexpression of oncogenes linking these pathway interactions to disease states.
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Terms & Conditions.
Allele-1: 29 bp deletion in exon 1
Allele-2: 23 bp deletion in exon 1
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