Human STX10 knockout HEK-293T cell lysate

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

STX10 also known as Syntaxin 10 is a protein involved in membrane trafficking. It functions as a t-SNARE protein important for vesicular transport between cellular compartments. STX10 has a molecular mass of approximately 35 kDa. This protein is expressed in various tissues prominently in the brain and heart. By mediating vesicle fusion STX10 plays a central role in the distribution of proteins and lipids necessary for cell homeostasis and signaling.

Biological function summary

The protein Syntaxin 10 contributes to the trans-Golgi network and endosome system. It acts as part of the SNARE complex interacting with other SNARE proteins like Vti1a and VAMP3 to facilitate the tethering and fusion of transport vesicles. Through these interactions STX10 ensures the correct delivery of cargo to target membranes impacting processes like cell communication and maintenance of cellular structure.

Pathways

This protein Syntaxin 10 participates in the Golgi-to-endosome transport pathway and endosomal-lysosomal transport. In these pathways STX10 closely associates with proteins like STX16 and VTI1A which collaborate in endosomal cargo selection and vesicle formation. These interactions are essential for maintaining membrane dynamics and protein sorting supporting cellular logistics and waste disposal within cells.

Associated diseases and disorders

Alterations involving Syntaxin 10 have links to neurological disorders such as Alzheimer's disease and neurodevelopmental conditions. Abnormal function or expression of STX10 can interfere with intracellular trafficking contributing to amyloid-beta peptide accumulation observed in Alzheimer's. Through these disease mechanisms other proteins like APP (amyloid precursor protein) are also affected illustrating the interconnectedness of cellular trafficking proteins and neurodegenerative processes.