Human UTP11L knockout HEK-293T cell lysate
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UTP11 KO cell lysate available now. KO validated by. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 1 and Insertion of the selection cassette in exon 1.
View Alternative Names
CGI 94, Probable U3 small nucleolar RNA-associated protein 11, U3 snoRNA-associated protein 11, UTP11 like U3 small nucleolar ribonucleoprotein, UTP11-like protein, UTP11_HUMAN
- Sanger seq
Unknown
Sanger Sequencing - Human UTP11L knockout HEK-293T cell lysate (AB263413)
Allele-2 : Insertion of the selection cassette in exon 1
- Sanger seq
Unknown
Sanger Sequencing - Human UTP11L knockout HEK-293T cell lysate (AB263413)
Allele-1 : 1 bp insertion in exon 1
Product details
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.
What's included?
Properties and storage information
Gene name
Gene editing type
Gene editing method
Knockout validation
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
UTP11L functions as an essential component of the U3 small nucleolar ribonucleoprotein (snoRNP) complex. This complex plays a pivotal role in the early cleavage steps of pre-rRNA processing an important stage in ribosome biogenesis. UTP11L facilitates the proper assembly and stabilization of this complex ensuring efficient processing of rRNA precursors into functional ribosomal RNA. These processes occur within the nucleolus the main hub for ribosome production in the cell.
Pathways
UTP11L is integral to the ribosome biogenesis and RNA processing pathways. Its interaction with the snoRNP components such as fibrillarin and NOP56 highlights its involvement in the maturation of 18S rRNA an important step for ribosomal subunit assembly. Through these pathways UTP11L aligns with other ribosomal proteins and snoRNP-associated factors playing an extensive role in maintaining the fidelity and efficiency of ribosomal function.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 2 US: 2
Adherent/suspension
Adherent
Gender
Female
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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