LYPD2 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LYPD2 also known as Lynx Homolog 2 plays a mechanical role in cellular communication through its function as a glycosylphosphatidylinositol (GPI)-anchored protein. The mass of LYPD2 is approximately 15 kDa. This protein is expressed mainly in tissues of the digestive and respiratory systems along with some parts of the nervous system. Its expression patterns suggest its importance in the normal functioning of these areas.

Biological function summary

The activities of LYPD2 influence various cellular processes specifically in the modulation of cell signaling. It is not part of a larger protein complex but acts individually as a modulator in the extracellular matrix. LYPD2 affects signal transmission particularly in neurons and epithelial cells which relates to its expression in the nervous and digestive systems.

Pathways

The participation of LYPD2 connects to cholinergic signaling where it interacts with acetylcholine receptors. These interactions influence the muscarinic and nicotinic pathways both critical for neuronal and muscle synapse functions. Additionally LYPD2 shares pathway connections with neuromodulatory proteins like Lynx1 indicating a shared role in neurotransmission.

Researchers link LYPD2 to conditions like Parkinson's disease and asthma. The protein's role in acetylcholine signaling appears to contribute to the pathophysiology of Parkinson's disease due to disrupted neurotransmission. In asthma LYPD2's expression and modulation in respiratory tissues possibly involve inter-reactions with Lynx1 suggesting alterations in the normal signaling pathway associated with respiratory distress.