RERG overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The RERG protein also known as RAS-like estrogen-regulated growth-inhibitor is a small GTPase with a molecular mass of approximately 25 kDa. RERG belongs to the RAS superfamily of GTPases acting as a molecular switch by cycling between active GTP-bound and inactive GDP-bound states. It is expressed in various tissues but shows high levels in estrogen receptor-positive breast cancer cells. The protein engages with nucleotide binding hydrolysis and possibly further cellular functions.

Biological function summary

RERG influences cell growth and proliferation. While not part of a larger complex RERG impacts estrogen-responsive signaling pathways. Its expression correlates with reduced cellular growth suggesting a suppressor function in certain contexts. Research shows its involvement in cellular processes that may oppose cancerous transformation particularly in hormone-responsive tissues.

Pathways

RERG impacts signaling pathways involved with estrogen receptor signaling and cell cycle regulation. It associates with other RAS superfamily proteins through its role in these pathways modulating growth and division in response to hormonal changes. ERK/MAPK pathways also interact with RERG influencing its ability to regulate cellular responses to external stimuli.

Research highlights RERG's role in breast cancer where it may act as a potential suppressor. RERG expression inversely relates to tumor progression in estrogen receptor-positive breast cancer linking it with survival outcomes. Additionally alterations in RERG are investigated in other hormone-sensitive cancers although less extensively. The protein has connections with other GTPases such as RAS influencing carcinogenic pathways and offering potential therapeutic targets.