RGS3 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGS3 also known as Regulator of G-protein Signaling 3 acts mechanically by deactivating G-proteins which are involved in transmitting signals from cell surface receptors to the inside of the cell. The protein is a GTPase-activating protein (GAP) which accelerates the termination of signal transduction. Typically RGS3 has a mass of approximately 90 kDa. It is expressed in diverse tissues such as the heart kidney and various areas within the central nervous system indicating its broad physiological roles.

Biological function summary

This target modulates signaling pathways that control various cellular processes. RGS3 functions as part of regulatory complexes that influence cell proliferation differentiation and migration. The protein interacts with multiple G-protein-coupled receptors (GPCRs) playing roles in cardiac development and function. Such interactions are critical in maintaining cellular homeostasis and responding to external stimuli.

Pathways

RGS3 takes part in the G-protein signaling pathway and the mitogen-activated protein kinase (MAPK) pathway. Within the G-protein signaling pathway RGS3 accelerates GTP hydrolysis on the G-alpha subunit facilitating the reformation of the inactive G-protein. It also interacts with proteins such as Raf1 in the MAPK pathway highlighting its regulatory role in controlling cell division and growth.

Alterations in RGS3 expression link to conditions such as cardiac hypertrophy and certain cancers. In cardiac hypertrophy aberrations in RGS3 levels may disturb GPCR signaling contributing to abnormal cardiac growth. The protein's connection with other key regulators like Raf1 in cancer further asserts its relevance. These interactions make RGS3 a potential target for therapeutic intervention in these diseases.