Rsk 2 / MAPKAP Kinase 1b overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Rsk 2 also known as MAPKAP Kinase 1b is a 60- to 90-kilodalton serine/threonine kinase belonging to the RSK family. It plays an important role in cell signaling by phosphorylating various substrates. The protein is expressed in many tissues including the brain heart and liver. Rsk 2 contains two distinct catalytic domains which allow it to carry out its functions efficiently. Activation of this protein involves its interaction with ERK/MAPK signaling proteins.

Biological function summary

Rsk 2 is a central player in the regulation of cell growth survival and motility. It exists as part of the larger MAPK/ERK pathway where it acts downstream of ERK1/2. Upon activation Rsk 2 phosphorylates target proteins which regulate gene expression cell cycle progression and apoptosis. This allows it to control multiple aspects of cell physiology contributing to proper cellular responses to external stimuli.

Pathways

The protein Rsk 2 integrates into the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are essential for controlling processes such as proliferation and differentiation. Rsk 2 activation depends on upstream kinases like MEK and ERK. In the MAPK/ERK pathway it collaborates with other kinases and transcription factors to mediate cellular responses. This involvement places Rsk 2 at a nexus of signaling events that finely tune cell function and fate.

Rsk 2 mutations can lead to Coffin-Lowry syndrome which is a form of intellectual disability accompanied by physical abnormalities. The protein has also been implicated in certain cancer types whereby its upregulation supports tumor growth and survival. In these contexts interactions between Rsk 2 and proteins such as ERK and AKT contribute to the pathological alterations that occur in these diseases. The ongoing study of Rsk 2 holds potential for understanding and targeting conditions where it plays a role.