SIVA overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SIVA also known as CD27-binding protein SIVA is a pro-apoptotic protein involved in cell death mechanisms. This protein typically weighs around 15 kDa and predominantly locates in the cytoplasm and the nucleus of cells. It expresses in a variety of tissues including immune system organs like the thymus and spleen reflecting its integral role in immune function and development.

Biological function summary

SIVA impacts apoptosis regulation through its interaction with signaling pathways that mediate cell death. It binds to the CD27 receptor a member of the tumor necrosis factor receptor (TNFR) family which is critical for the induction of apoptosis. SIVA is known to interact with other proteins such as those in the Bcl-2 family which further emphasize its role in orchestrating cell death programs.

Pathways

Various apoptotic cascades involve SIVA notably the extrinsic apoptotic signaling pathway linked to the TNFR family. This pathway engages the FasL/Fas and TNFR1 complexes where SIVA functions alongside other apoptosis regulators like caspases. SIVA also interfaces with proteins like TRAFs (tumor necrosis factor receptor-associated factors) which modulate signaling pathways related to immune responses and cell survival.

Research links SIVA to cancer and autoimmune conditions. In cancer SIVA’s modulation of apoptosis can influence tumor progression and chemotherapy resistance often through its interaction with Bcl-2 proteins that inhibit cell death. Similarly in autoimmune diseases where immune cell regulation is disrupted SIVA's role affects T-cell survival and overall immune responses connecting it with disorders where TNFR family signaling plays a part.