STAP-1 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STAP-1 also known as Signal Transducing Adaptor Protein-1 has a mass of approximately 31 kDa. Mechanically STAP-1 functions as an adaptor protein that engages in signaling pathways. This protein interacts with several signaling molecules to modulate cellular responses. STAP-1 shows expression in immune cells especially in B-cells and T-cells indicating its role in immune system regulation.

Biological function summary

STAP-1 modulates the signaling pathways that govern cell growth and differentiation. It participates in forming complexes with other proteins to transduce signals from the cell surface to the nucleus. STAP-1's ability to bind phosphotyrosine residues allows it to act as a scaffold for other signaling molecules in immune responses. Its interaction with other pathway proteins suggests its role in cellular processes beyond immunity influencing various cellular outcomes.

Pathways

STAP-1 integrates into the JAK-STAT signaling pathway and the PI3K-Akt pathway. These pathways play a central role in regulating immune cell function and proliferation. STAP-1 associates with proteins such as STAT3 and PI3K linking it to important signaling cascades that control gene expression and cell survival. In the JAK-STAT pathway STAP-1's interaction with STAT proteins emphasizes its involvement in transmitting extracellular cues to the nucleus.

STAP-1 connects to autoimmune diseases and certain cancers. Abnormal STAP-1 expression or function can impact immune system regulation potentially contributing to conditions such as lupus or leukemia. STAP-1 associates with proteins like BCR-ABL in the context of leukemia linking it to malignancy pathways. Investigation into STAP-1's role in these disorders provides insights into its potential as a therapeutic target.