Synphilin 1 overexpression 293T lysate (whole cell)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synphilin-1 also known as SNCAIP is a protein that plays a role in cellular mechanisms. It has a molecular mass of approximately 90 kDa. Synphilin-1 is expressed in various tissues with high levels seen in the brain particularly within neurons. This protein undergoes interactions with other cellular components and participates in the regulation of protein aggregation which is critical in maintaining cellular homeostasis.

Biological function summary

Synphilin-1 associates with alpha-synuclein to form complexes that influence neuronal function. It participates in the modulation of synaptic activity and neuronal signaling. The protein functions as a scaffold supporting various signaling molecules and influencing their activity. Synphilin-1's role in these processes highlights its importance in maintaining neural cell health and function.

Pathways

Synphilin-1 influences the ubiquitin-proteasome system that is responsible for protein degradation and turnover. This involvement links Synphilin-1 to the degradation of misfolded proteins a function that is shared with ubiquitin ligases. Another pathway of interest is the endoplasmic reticulum-associated degradation (ERAD) pathway where Synphilin-1 mediates the removal of aberrant proteins. Synphilin-1’s association with the ubiquitin-proteasome pathway and its interactions with related proteins like parkin provide insight into its regulatory functions.

Synphilin-1 exhibits a significant connection to neurodegenerative diseases such as Parkinson's disease. Its interaction with alpha-synuclein an important player in this disorder highlights its involvement in disease pathogenesis. Additionally Synphilin-1 has been linked to Alzheimer's disease where its aggregation-modulating properties may influence disease progression. These relationships make Synphilin-1 a target of interest for therapeutic research in the context of neurodegeneration.