Ube2L6 overexpression 293T lysate (whole cell)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ube2L6 also known as UbcH8 is an E2 ubiquitin-conjugating enzyme with a molecular weight of about 19 kDa. It functions in the ubiquitin-proteasome pathway by transferring ubiquitin from an E1 activating enzyme to an E3 ligase assisting in protein degradation. Ube2L6 is expressed in many tissues including spleen liver and lymph nodes highlighting its varied role in cellular processes.

Biological function summary

Ube2L6 contributes to protein quality control within the cell. The enzyme participates in the post-translational modification of proteins specifically tagging misfolded or damaged proteins with ubiquitin for degradation. It interacts with several E3 ligases and forms part of the larger ubiquitin-proteasome complex. This function helps maintain protein homeostasis.

Pathways

Ube2L6 plays a role in both the NF-kB signaling and type I interferon pathways. In the NF-kB signaling pathway it facilitates the degradation of inhibitory proteins allowing nuclear translocation of NF-kB and subsequent gene expression. It associates with proteins such as TRAF6 which is important for the activation of NF-kB. In type I interferon signaling Ube2L6 aids in the antiviral response by assisting in the modification of target proteins enhancing the immune defense.

Associated diseases and disorders

Ube2L6 relates to cancer and autoimmune conditions. In cancer its correlation with TRAF6 can influence tumor cell survival and proliferation through the NF-kB pathway. Regarding autoimmune conditions aberrant function of Ube2L6 might affect immune system responses contributing to diseases like lupus. Its regulation becomes important for maintaining normal cellular functions and preventing disease progression.