ELISA kits play a vital role in drug discovery by enabling precise quantification of biomarkers that signal efficacy, toxicity, and pharmacodynamic responses. In early-stage screening and preclinical studies, liver toxicity ELISA kits help detect hepatotoxic markers such as ALT, AST, and albumin, providing early warnings of adverse effects. Meanwhile, Host Cell Protein (HCP) ELISA kits are essential for biologics development, ensuring residual proteins from production cells, like CHO or E. coli, are accurately measured and minimized to meet regulatory standards. These assays offer high sensitivity, reproducibility, and scalability, making them indispensable for evaluating candidate safety, optimizing formulations, and supporting regulatory submissions.

ELISA kits are also adaptable to 384-well plate format to support higher-throughput applications and reduce sample volume requirements, making them well-suited for drug discovery workflows and screening campaigns.

ELISA kits to assess hepatotoxicity

Our ELISA kits and assays for assessing hepatotoxicity (liver toxicity) allow for efficient measurement of key markers, such as Albumin, Alanine Transaminase (ALT), Aspartate Aminotransferase (AST), gamma-glutamyl transferase (GGT), and bilirubin. For quantification purposes, our SimpleStep ELISA kits yield results within 90 minutes and are available in a 384-well format for increased throughput.

Albumin, AST, and ALT SimpleStep® ELISA kits are also available for murine and rat samples.

Product highlights

ELISA kits to measure Host Cell Protein (HCP)

ELISA assays for Host Cell Proteins (HCPs) are critical tools in biologics manufacturing, used to detect and quantify residual proteins from production cell lines such as CHO or E. coli. These impurities, if not adequately removed, can affect product safety, efficacy, and immunogenicity. HCP ELISA kits offer high sensitivity and broad coverage, enabling manufacturers to monitor purification processes and ensure compliance with regulatory standards.

We offer generic host cell protein ELISA kits for CHO and E. coli (ab240996and ab240997), but also individual HCP ELISA kits to detect high-risk CHO proteins like PLBL2 (phospholipase B-Like 2), clusterin, etc.

384-well ELISA kits

Drug Discovery often involves screening a large number of samples with limited volumes with a fast turnaround time.

Our 384-well SimpleStep ELISA® kits use a 90-minute, single-wash protocol to measure up to 180 samples in duplicates. They use only 12.5 μL of the final sample volume. These kits are also ideal for assaying supernatants of cells or organoids grown in 384-well plates, as they maintain the sample mapping and traceability, making it easier to read results. We offer a 384-well format for a large number of our SimpleStep ELISA® kits. Please ask us for 384-well upvalidation.