Human Anti-Adenovirus IgG ELISA Kit is an indirect ELISA for the qualitative detection of IgG class antibodies against Adenovirus in human plasma and serum samples.
- Colorimetric readout - 450 nm - Works on any standard plate reader
- Easy results interpretation
- Cut-off, positive and negative controls included
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
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Human Anti-Adenovirus IgG ELISA Kit is an indirect ELISA for the qualitative detection of IgG class antibodies against Adenovirus in human plasma and serum samples.
- Colorimetric readout - 450 nm - Works on any standard plate reader
- Easy results interpretation
- Cut-off, positive and negative controls included
| Sample | n | C.V. |
|---|---|---|
Sample Serum | n 24 | C.V. 6.1 |
| Sample | n | C.V. |
|---|---|---|
Sample Serum | n 12 | C.V. 4.3 |
Abcam's anti-Adenovirus IgG Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate qualitative measurement of IgG class antibodies against Adenovirus in Human serum and plasma.
A 96-well plate has been precoated with Adenovirus antigens to bind cognate antibodies. Controls or test samples are added to the wells and incubated. Following washing, a horseradish peroxidase (HRP) labelled anti-Human IgG conjugate is added to the wells, which binds to the immobilized Adenovirus-specific antibodies. TMB is then catalyzed by the HRP to produce a blue color product that changes to yellow after adding an acidic stop solution. The density of yellow coloration is directly proportional to the amount of Adenovirus IgG sample captured in plate.
Adenovirus IgG refers to immunoglobulin G antibodies that target adenoviruses which are non-enveloped viruses known for their icosahedral capsid structure. These antibodies play an essential role in immune response against adenovirus infections a common cause of respiratory illnesses gastroenteritis and conjunctivitis. The molecular mass of adenovirus IgG can vary depending on the specific structure of the antibody and the antigens it targets. Adenovirus IgG is typically expressed in serum and other bodily fluids as part of the humoral immune response. It is often measured to assess exposure to adenoviruses.
Adenovirus-specific IgG contributes to viral neutralization and helps in clearing adenovirus infections from the body. These antibodies can also promote antibody-dependent cellular cytotoxicity and complement activation enhancing the immune defense. Adenovirus IgG is not part of any stable protein complex but it interacts dynamically within the immune system to target viral proteins on the surface of infected cells. This interaction prevents the spread of the virus within the host.
Adenovirus IgG plays a significant role within the adaptive immune response particularly focusing on targeting and neutralizing free viral particles and infected cells. It works closely with other immunoglobulins and immune cells such as T cells in the immune pathways responsible for recognizing and responding to pathogen-associated molecular patterns. The IgG antibodies generated during an infection also enhance opsonization leading to more efficient phagocytosis by immune cells like macrophages and neutrophils.
Adenovirus IgG levels often indicate past infections or immunity status concerning adenovirus-related illnesses such as upper respiratory tract infections and keratoconjunctivitis. While rarely causing severe diseases in healthy individuals adenoviruses hold greater relevance in immunocompromised patients where IgG response might not suffice to control viral spread. The production of adenovirus IgG and its efficacy depends on interaction with other proteins involved in the immune system including cytokines and chemokines which regulate the broader immune response to infection.
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