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AB108705

Human Anti-Adenovirus IgG ELISA Kit

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(1 Publication)

Human Anti-Adenovirus IgG ELISA Kit is an indirect ELISA for the qualitative detection of IgG class antibodies against Adenovirus in human plasma and serum samples.

- Colorimetric readout - 450 nm - Works on any standard plate reader
- Easy results interpretation
- Cut-off, positive and negative controls included

Key facts

Detection method

Colorimetric

Sample types

Citrate plasma, Heparin Plasma, Serum

Reacts with

Human

Assay type

Indirect

Assay Platform

Microplate

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Abcam's anti-Adenovirus IgG Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate qualitative measurement of IgG class antibodies against Adenovirus in Human serum and plasma.

A 96-well plate has been precoated with Adenovirus antigens to bind cognate antibodies. Controls or test samples are added to the wells and incubated. Following washing, a horseradish peroxidase (HRP) labelled anti-Human IgG conjugate is added to the wells, which binds to the immobilized Adenovirus-specific antibodies. TMB is then catalyzed by the HRP to produce a blue color product that changes to yellow after adding an acidic stop solution. The density of yellow coloration is directly proportional to the amount of Adenovirus IgG sample captured in plate.

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

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Precision

[ { "reproducibilityType": "Inter", "sample": "Serum", "replicates": 12, "mean": null, "standardDeviation": null, "coefficientOfVariability": "4.3" }, { "reproducibilityType": "Intra", "sample": "Serum", "replicates": 24, "mean": null, "standardDeviation": null, "coefficientOfVariability": "6.1" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab108705-1x96Tests", "assetComponentDetails": [ { "size":"1 x 20 mL", "name":"Adenovirus anti-IgG HRP Conjugate", "number":"AB108705-CMP05", "productcode":"" }, { "size":"1 x 3 mL", "name":"Adenovirus IgG Cut-off Control", "number":"AB108705-CMP07", "productcode":"" }, { "size":"1 x 2 mL", "name":"Adenovirus IgG Negative Control", "number":"AB108705-CMP08", "productcode":"" }, { "size":"1 x 2 mL", "name":"Adenovirus IgG Positive Control", "number":"AB108705-CMP09", "productcode":"" }, { "size":"1 x 100 mL", "name":"IgG Sample Diluent", "number":"AB108705-CMP01", "productcode":"" }, { "size":"1 x 50 mL", "name":"20X Washing Solution", "number":"AB108705-CMP04", "productcode":"" }, { "size":"1 x 15 mL", "name":"Stop Solution", "number":"AB108705-CMP11", "productcode":"" }, { "size":"1 x 15 mL", "name":"TMB Substrate Solution", "number":"AB108705-CMP03", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Adenovirus (IgG) Coated Microplate (12 x 8 wells)", "number":"AB108705-CMP06", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Cover foil", "number":"AB108705-CMP02", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Strip holder", "number":"AB108705-CMP10", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Adenovirus IgG refers to immunoglobulin G antibodies that target adenoviruses which are non-enveloped viruses known for their icosahedral capsid structure. These antibodies play an essential role in immune response against adenovirus infections a common cause of respiratory illnesses gastroenteritis and conjunctivitis. The molecular mass of adenovirus IgG can vary depending on the specific structure of the antibody and the antigens it targets. Adenovirus IgG is typically expressed in serum and other bodily fluids as part of the humoral immune response. It is often measured to assess exposure to adenoviruses.
Biological function summary

Adenovirus-specific IgG contributes to viral neutralization and helps in clearing adenovirus infections from the body. These antibodies can also promote antibody-dependent cellular cytotoxicity and complement activation enhancing the immune defense. Adenovirus IgG is not part of any stable protein complex but it interacts dynamically within the immune system to target viral proteins on the surface of infected cells. This interaction prevents the spread of the virus within the host.

Pathways

Adenovirus IgG plays a significant role within the adaptive immune response particularly focusing on targeting and neutralizing free viral particles and infected cells. It works closely with other immunoglobulins and immune cells such as T cells in the immune pathways responsible for recognizing and responding to pathogen-associated molecular patterns. The IgG antibodies generated during an infection also enhance opsonization leading to more efficient phagocytosis by immune cells like macrophages and neutrophils.

Adenovirus IgG levels often indicate past infections or immunity status concerning adenovirus-related illnesses such as upper respiratory tract infections and keratoconjunctivitis. While rarely causing severe diseases in healthy individuals adenoviruses hold greater relevance in immunocompromised patients where IgG response might not suffice to control viral spread. The production of adenovirus IgG and its efficacy depends on interaction with other proteins involved in the immune system including cytokines and chemokines which regulate the broader immune response to infection.
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Product protocols

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Target data

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy oncolytics 25:31-42 PubMed35399603

2022

Intraperitoneal oncolytic virotherapy for patients with malignant ascites: Characterization of clinical efficacy and antitumor immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Yalei Zhang,Ling Qian,Kun Chen,Sijia Gu,Jia Wang,Zhiqiang Meng,Ye Li,Peng Wang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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