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AB313507

Human ANGPTL7 ELISA Kit

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Human ANGPTL7 ELISA Kit is a Sandwich ELISA for the measurement of Human ANGPTL7 in Human in Cell Culture Media, Biofluids samples.

View Alternative Names

CDT6, UNQ313/PRO356, ANGPTL7, Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein

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Sandwich ELISA - Human ANGPTL7 ELISA Kit (AB313507)
  • sELISA

Supplier Data

Sandwich ELISA - Human ANGPTL7 ELISA Kit (AB313507)

Example of standard curve using ab313507. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Cell culture supernatant, Plasma, Serum

Reacts with

Human

Assay type

Sandwich

Results type

Quantitative

Sensitivity

= 0.05 ng/mL

Range

0.05 - 12 ng/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

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Complementary Products

Primary Antibodies

AB199179

Anti-ANGPTL7 antibody

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Human ANGPTL7 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human ANGPTL7 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human ANGPTL7 coated on a 96-well plate.
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Recovery

[ { "sample": "Cell culture media", "range": "97 - 117 %", "average": "= 105.1" }, { "sample": "Plasma", "range": "71 - 117 %", "average": "= 85.93" }, { "sample": "Serum", "range": "80 - 119 %", "average": "= 98.37" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313507-1x96Tests", "assetComponentDetails": [ { "size":"1 x 1 Unit", "name":"Human ANGPTL7 Antibody-coated ELISA Plate", "number":"AB313507-CMP08", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313507-CMP06", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human ANGPTL7 Protein Standard", "number":"AB313507-CMP10", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313507-CMP04", "productcode":"" }, { "size":"1 x 200 µL", "name":"200X HRP-Streptavidin", "number":"AB313507-CMP03", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human ANGPTL7 Detection Antibody", "number":"AB313507-CMP09", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313507-CMP07", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB313507-CMP05", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ANGPTL7 protein also known as Angiopoietin-like 7 plays a role in mechanistic processes. It has a molecular mass of about 45 kDa. ANGPTL7 is expressed primarily in the cornea and trabecular meshwork of the eye but it is also found in other tissues like the liver and heart. This protein is part of the larger angiopoietin-like protein family which is involved in numerous functions related to angiogenesis and metabolism.
Biological function summary

ANGPTL7 participates in the regulation of extracellular matrix composition and collagen deposition affecting tissue remodeling. It does not form a known complex with other molecules but influences the structural integrity of tissues through its regulatory actions. ANGPTL7 potentially interacts with cellular receptors to mediate these effects contributing to maintenance and repair of tissue structures.

Pathways

ANGPTL7 interacts within the framework of the TGF-beta signaling pathway influencing cellular growth and differentiation. Another important pathway involving ANGPTL7 is the Wnt signaling cascade which is important for various developmental processes. In these pathways ANGPTL7 has functional interactions with proteins such as TGF-beta and beta-catenin modulating their activity and impact on cellular functions.

ANGPTL7 has connections to ocular diseases like glaucoma where its expression levels alter the outflow facility of aqueous humor. It also relates to fibrosis since the regulation of collagen deposition is an important factor. The involvement of ANGPTL7 in these conditions links it with proteins such as myocilin in glaucoma and TIMP-1 in fibrosis highlighting its role in pathological tissue remodeling.
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Product protocols

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Target data

Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed : 21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed : 25622036).
See full target information ANGPTL7
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Product promise

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