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AB309455

Human Cadherin 13 ELISA

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Human Cadherin 13 ELISA is a Sandwich ELISA for the measurement of Human Cadherin 13 ELISA in Human in Biofluids, Cell Culture Media samples.

View Alternative Names

CDHH, CDH13, Cadherin-13, Heart cadherin, P105, Truncated cadherin, H-cadherin, T-cad, T-cadherin

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Sandwich ELISA - Human Cadherin 13 ELISA (AB309455)
  • sELISA

Supplier Data

Sandwich ELISA - Human Cadherin 13 ELISA (AB309455)

Example of standard curve using ab309455. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Serum, Plasma, Cell culture supernatant

Reacts with

Human

Assay type

Sandwich

Results type

Quantitative

Sensitivity

= 40 pg/mL

Range

40 - 10000 pg/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

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Complementary Products

Primary Antibodies

AB249422

Anti-H Cadherin antibody [EPR9621] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody [EPR9621] - BSA and Azide free (AB249422)

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Proteins & Peptides

AB134881

Recombinant Human H Cadherin protein

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Product details

Human Cadherin 13 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Cadherin 13 ELISA kit in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for human Cadherin 13 coated on a 96-well plate.
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Recovery

[ { "sample": "Serum", "range": "82 - 110 %", "average": "= 96.23" }, { "sample": "Plasma", "range": "78 - 141 %", "average": "= 114.3" }, { "sample": "Cell culture supernatant", "range": "81 - 136 %", "average": "= 118.5" }, { "sample": "Cell culture media", "range": "81 - 136 %", "average": "= 118.5" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab309455-1x96Tests", "assetComponentDetails": [ { "size":"1 x 200 µL", "name":"600X HRP-Streptavidin", "number":"AB309455-CMP12", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB309455-CMP02", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human Cadherin 13 Protein Standard", "number":"AB309455-CMP07", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB309455-CMP08", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human Cadherin 13 Detection Antibody", "number":"AB309455-CMP06", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB309455-CMP04", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB309455-CMP03", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human Cadherin 13 Antibody-coated ELISA Plate", "number":"AB309455-CMP09", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

H Cadherin also known as Cadherin-13 or T-cadherin is a unique member of the cadherin family of cell adhesion molecules. It weighs approximately 95 kDa. Unlike classical cadherins H Cadherin lacks the transmembrane and cytoplasmic domains anchoring instead to the membrane via a glycosylphosphatidylinositol (GPI) anchor. H Cadherin expresses in various tissues including endothelial cells cardiac muscle and neurons suggesting its versatile role in different biological contexts.
Biological function summary

The protein plays a role in cell-cell interactions and tissue organization without forming typical adherens junctions. Researchers have identified H Cadherin as a part of the significant complex involved in neural network formation vascular patterning and cardiac tissue integrity. In neurons its expression modulates axon growth and guidance. In the cardiovascular system it contributes to heart function and blood vessel maintenance through its adhesive properties and involvement in signaling pathways.

Pathways

Several biological networks incorporate H Cadherin as an important element. Notably it participates in the Wnt signaling and PI3K/AKT pathways. H Cadherin interacts with proteins such as β-catenin in the Wnt pathway influencing cellular responses like proliferation and differentiation. In the PI3K/AKT pathway the protein may affect cell survival and metabolism. These interactions illustrate H Cadherin's involvement in important cellular processes.

H Cadherin has significant associations with cardiovascular diseases and certain cancers. Altered expression levels or mutations in H Cadherin can disrupt cellular adhesion and signaling contributing to the progression of atherosclerosis and tumor formation. In cancer linkages between H Cadherin and other cadherin family members like E-cadherin suggest complex interactions that can modulate tumor cell behavior influencing invasion and metastasis.
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Product protocols

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
See full target information CDH13
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websiteProtocolBooklet
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Product promise

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