JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB314828

Human Cathepsin X ELISA Kit

Be the first to review this product! Submit a review

|

(0 Publication)

Human Cathepsin X ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Cathepsin X in Human in Biofluids, Cell Culture Media samples.

View Alternative Names

Cathepsin Z, Cathepsin P, Cathepsin X, CTSZ

1 Images
Sandwich ELISA - Human Cathepsin X ELISA Kit (AB314828)
  • sELISA

Supplier Data

Sandwich ELISA - Human Cathepsin X ELISA Kit (AB314828)

Example of standard curve using ab314828. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Serum, Plasma, Cell culture supernatant

Reacts with

Human

Assay type

Sandwich (quantitative)

Sensitivity

= 1.5 pg/mL

Range

1.5 - 400 pg/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

Product details

Human Cathepsin X ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Cathepsin X in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human Cathepsin X coated on a 96-well plate.
style
left-column

Recovery

[ { "sample": "Serum", "range": "74 - 133 %", "average": "= 95.9" }, { "sample": "Plasma", "range": "80 - 135 %", "average": "= 121.1" }, { "sample": "Cell culture media", "range": "105 - 140 %", "average": "= 120.2" } ]
style
left-column

What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab314828-1x96Tests", "assetComponentDetails": [ { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB314828-CMP07", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB314828-CMP04", "productcode":"" }, { "size":"1 x 200 µL", "name":"100X HRP-Streptavidin", "number":"AB314828-CMP03", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human Cathepsin X Detection Antibody", "number":"AB314828-CMP09", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human Cathepsin X Antibody-coated ELISA Plate", "number":"AB314828-CMP08", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB314828-CMP06", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB314828-CMP05", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human Cathepsin X Protein Standard", "number":"AB314828-CMP10", "productcode":"" } ] } } }
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cathepsin Z also known as cathepsin X or CTSZ is a lysosomal cysteine protease with a molecular weight of approximately 34 kDa. It is expressed mainly in immune cells such as macrophages and dendritic cells but also found in other tissues including liver kidney and spleen. This protease performs proteolytic functions which involve cleaving peptide bonds in proteins contributing to protein catabolism in cells. The widespread expression of Cathepsin Z suggests its involvement in various physiological processes.
Biological function summary

Cathepsin Z participates in immune response regulation and cellular adhesion processes. It belongs to the papain-like cysteine protease family. Notably it associates with integrins to influence cell-extracellular matrix interactions affecting cell migration and adhesion. By modulating these processes Cathepsin Z impacts immune surveillance and tissue remodeling demonstrating its multifaceted role in maintaining cellular homeostasis.

Pathways

Cathepsin Z engages significantly in apoptotic and antigen-presenting pathways. In apoptosis it influences cell death by degrading specific substrates involved in cell survival. It also assists in the processing of antigens within dendritic cells facilitating effective antigen presentation to T cells. Related proteins such as Cathepsin S and Cathepsin L which also partake in lysosomal pathways further illustrate the shared functionality and redundancy within this protease family enabling a robust regulatory network.

Cathepsin Z has implications in cancer progression and neurodegenerative diseases. It is often overexpressed in cancerous tissues where it aids tumor cell invasion and metastasis through degradation of extracellular components. Additionally alterations in Cathepsin Z activity are linked to Alzheimer's disease where it may affect the processing of amyloid precursor proteins similar to its interaction with other proteins like Cathepsin B. These connections highlight the potential for Cathepsin Z as a target for therapeutic intervention in various pathological conditions.
style
left-column

Product protocols

style
left-column

Target data

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed : 10504234). Capable of producing kinin potentiating peptides (By similarity).
See full target information Cathepsin Z
style
left-column
style
left-column
websiteProtocolBooklet
en
style
right-column

Complementary Products

Assay Kits

AB119586

Human Cathepsin D ELISA Kit

Sandwich ELISA - Human Cathepsin D ELISA Kit (AB119586)

  • 0
  • 0
Assay Kits

AB155427

Human Cathepsin S ELISA Kit (CTSS)

Sandwich ELISA - Human Cathepsin S ELISA Kit (CTSS) (AB155427)

  • 0
  • 0
Assay Kits

AB272205

Human Cathepsin B ELISA Kit

Recombinant|SimpleStep

ELISA - Human Cathepsin B ELISA Kit (AB272205)

  • 0
  • 0
Primary Antibodies

AB180580

Anti-Cathepsin Z antibody [EPR14357]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin Z antibody [EPR14357] (AB180580)

  • 5
  • 1

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com