JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB313687

Human DSCAML1 ELISA Kit

Be the first to review this product! Submit a review

|

(0 Publication)

Human DSCAML1 ELISA Kit is a Sandwich ELISA for the measurement of Human DSCAML1 in Human in Cell Culture Media, Biofluids samples.

View Alternative Names

DSCAM2, KIAA1132, DSCAML1, Cell adhesion molecule DSCAML1, Down syndrome cell adhesion molecule 2, Down syndrome cell adhesion molecule-like protein 1

1 Images
Sandwich ELISA - Human DSCAML1 ELISA Kit (AB313687)
  • sELISA

Supplier Data

Sandwich ELISA - Human DSCAML1 ELISA Kit (AB313687)

Example of standard curve using ab313687. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Cell culture supernatant, Plasma, Serum

Reacts with

Human

Assay type

Sandwich

Results type

Quantitative

Sensitivity

= 0.82 ng/mL

Range

0.82 - 200 ng/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

style
left-column

Complementary Products

Primary Antibodies

AB150761

Anti-DSCAML1 antibody [DS1-96]

Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-DSCAML1 antibody [DS1-96] (AB150761)

  • 0
  • 0
Proteins & Peptides

AB163552

Recombinant Human DSCAML1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human DSCAML1 protein (GST tag N-Terminus) (AB163552)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

Product details

Human DSCAML1 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human DSCAML1 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human DSCAML1 coated on a 96-well plate.
style
left-column

Recovery

[ { "sample": "Serum", "range": "94 - 134 %", "average": "= 117.7" }, { "sample": "Plasma", "range": "70 - 86 %", "average": "= 76.97" }, { "sample": "Cell culture media", "range": "135 - 147 %", "average": "= 142.6" } ]
style
left-column

What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313687-1x96Tests", "assetComponentDetails": [ { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313687-CMP07", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313687-CMP06", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human DSCAML1 Protein Standard", "number":"AB313687-CMP10", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB313687-CMP05", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313687-CMP04", "productcode":"" }, { "size":"1 x 200 µL", "name":"600X HRP-Streptavidin", "number":"AB313687-CMP03", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human DSCAML1 Antibody-coated ELISA Plate", "number":"AB313687-CMP08", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human DSCAML1 Detection Antibody", "number":"AB313687-CMP09", "productcode":"" } ] } } }
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein DSCAML1 also known as Down syndrome cell adhesion molecule-like 1 plays a mechanical role in cell adhesion and signaling. This protein with a mass of approximately 220 kDa belongs to the immunoglobulin superfamily. DSCAML1 is expressed in various tissues most notably in the nervous system where it helps in the development of neural circuits. The target is known for its complex structure which allows it to mediate homophilic cell-cell interactions essential for neuronal positioning and axonal pathfinding.
Biological function summary

DSCAML1 is involved in neural patterning and synaptic connectivity. The protein contributes to neural migration processes during development ensuring proper brain morphogenesis. Research suggests that DSCAML1 forms part of a molecular complex that aids in axon guidance important for network formation within the brain. Together with other cell adhesion molecules DSCAML1 influences synapse formation and stability impacting neural networks' functional integrity.

Pathways

DSCAML1 participates in signaling pathways critical for nervous system development. It significantly influences axon guidance and synaptic signaling pathways. DSCAML1 interacts with other proteins like DSCAM and DCC (Deleted in Colorectal Cancer) which are known to play roles in cellular communication and neuronal growth processes. These interactions contribute to the proteins' collective ability to orchestrate developmental and functional aspects of the central nervous system.

DSCAML1 mutations have associations with neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. Alterations in DSCAML1 functions may disrupt neural circuitry leading to these conditions. Proteins like DSCAM whose gene duplication or mutations often occur in Down syndrome share pathways or functions with DSCAML1 and disruptions in these interactions stand linked to altered neural development and related cognitive concerns.
style
left-column

Product protocols

style
left-column

Target data

Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed : 11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina : expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).
See full target information DSCAML1
style
left-column
style
left-column
websiteProtocolBooklet
en
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com