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AB313603

Human FCRL5 ELISA Kit

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Human FCRL5 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human FCRL5 in Human in Cell Culture Media, Biofluids samples.

View Alternative Names

CD307e, FCRH5, IRTA2, UNQ503/PRO820, FCRL5, Fc receptor-like protein 5, FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, Immune receptor translocation-associated protein 2, FcRH5

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Sandwich ELISA - Human FCRL5 ELISA Kit (AB313603)
  • sELISA

Supplier Data

Sandwich ELISA - Human FCRL5 ELISA Kit (AB313603)

Example of standard curve using ab313603. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Cell culture supernatant, Plasma, Serum

Reacts with

Human

Assay type

Sandwich (quantitative)

Sensitivity

= 1.64 ng/mL

Range

1.64 - 400 ng/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Human FCRL5 (Fc Receptor-Like 5) ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human FCRL5 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human FCRL5 coated on a 96-well plate.

This ELISA kit shows no cross-reactivity with the following cytokines tested: human Activin RIIA, Biglycan, CA13, CA2, CA72-4, CLEC-2, C-myc, Cystatin D, Erythropoietin, FGF-16, GATA-4, GFR alpha-1, GFR alpha-2, Granzyme B, Granzyme H, HIF1a, htPAPP-A, IFNb, IL-17RC, IL-19, IL 20R beta, IL-22, ILT-4, LAIR2, LSECtin, Netrin-4, Norrin, NRG1a, PD-L2, PDX-1, Podovalyxin, RGM-C, S100A1, Semaphorin 6A, SLITRK5, SR-AI, ST6GAL1, Thyroid Peroxidase, Troponin C.

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Recovery

[ { "sample": "Serum", "range": "68 - 81 %", "average": "= 73.19" }, { "sample": "Plasma", "range": "69 - 77 %", "average": "= 71.81" }, { "sample": "Cell culture media", "range": "106 - 146 %", "average": "= 122.7" } ]
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What's included?

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FCRL5 also known as CD307 or Fc receptor-like 5 is a protein predominantly expressed on the surface of B cells and plasma cells. This protein weighs approximately 98 kDa. FCRL5 features structural similarities to classical Fc receptors suggesting a role in immune responses. Its expression is tightly regulated throughout B cell development and has been detected in lymphoid tissues with higher levels reported in bone marrow and secondary lymphoid organs.
Biological function summary

FCRL5 modulates the immune system by influencing B cell activation and differentiation. It participates in the formation of immune complexes playing a dual role in both promoting and inhibiting immune responses depending on the surrounding conditions. This regulatory function suggests that FCRL5 can adjust immune system activities to maintain homeostasis. It acts independently and might form complexes with other immune regulatory proteins to fine-tune B cell responses.

Pathways

FCRL5 plays a role in the adaptive immune response and is associated with the B cell receptor (BCR) signaling pathway. It interacts with proteins such as CD19 and CD79 influencing downstream signaling cascades critical for B cell maturation and effector functions. The interaction of FCRL5 with these pathways highlights its importance in modulating signal transduction that leads to cytokine production and antibody generation.

FCRL5 has been implicated in the pathogenesis of autoimmune diseases and certain hematological cancers such as chronic lymphocytic leukemia (CLL). Abnormal expression or mutations of FCRL5 can dysregulate normal B cell function contributing to disease development. In CLL FCRL5 potentially interacts with proteins like leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) influencing cancer cell survival and proliferation making it a target for therapeutic intervention and a potential biomarker for disease progression.
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Product protocols

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Target data

Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (PubMed : 30107486). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity).
See full target information FCRL5
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websiteProtocolBooklet
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