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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Human FDPS/FPS ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human FDPS/FPS in Human in Plasma, Serum, Cell culture supernatant samples.
Colorimetric
Plasma, Serum, Cell culture supernatant
Sandwich (quantitative)
Human
1.62 - 400 ng/mL
= 1.62 ng/mL
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application sELISA | Reactivity Reacts | Dilution info - | Notes - |
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Farnesyl pyrophosphate synthase, FPP synthase, FPS, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Human FDPS/FPS ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human FDPS/FPS in Human in Plasma, Serum, Cell culture supernatant samples.
Farnesyl pyrophosphate synthase, FPP synthase, FPS, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Colorimetric
Plasma, Serum, Cell culture supernatant
Sandwich (quantitative)
Human
1.62 - 400 ng/mL
Pre-coated microplate (12 x 8 well strips)
= 1.62 ng/mL
Sample type | Average % | Range |
---|---|---|
Sample type Serum | Average % = 107.9 | Range 95 - 118 % |
Sample type Plasma | Average % = 96.57 | Range 72 - 119 % |
Sample type Cell culture supernatant | Average % = 134.6 | Range 124 - 140 % |
Sample type Cell culture media | Average % = 134.6 | Range 124 - 140 % |
Blue Ice
-20°C
-20°C
Human FDPS/FPS ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CD42b in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for human FDPS/FPS coated on a 96-well plate.
Farnesyl diphosphate synthase facilitates the production of FPP a common precursor for the synthesis of isoprenoid compounds such as cholesterol ubiquinones and dolichol. FDPS does not form a complex but works in coordination with other enzymes in the mevalonate pathway. Its activity supports numerous cellular functions including membrane assembly protein prenylation and cell signaling. The enzyme’s role is important for normal cellular growth and development influencing processes like cell differentiation and proliferation.
Farnesyl diphosphate synthase (FDPS) also known as farnesyl pyrophosphate synthase (FPS) is an important enzyme that catalyzes the synthesis of farnesyl diphosphate (FPP) from isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). This enzyme plays an important role in the mevalonate pathway which is essential for the biosynthesis of sterols including cholesterol and other isoprenoids. FDPS is a protein with a molecular mass of approximately 42 kDa. Its expression occurs in various tissues with significant levels in liver brain and bone where it contributes to different cellular metabolic processes.
FDPS plays a significant role in the cholesterol biosynthesis and protein prenylation pathways. These pathways are critical for cellular homeostasis and involve several enzymes including HMG-CoA reductase and squalene synthase. The cholesterol biosynthesis pathway includes multiple steps where FPP serves as a lipid intermediate. Meanwhile in protein prenylation FPP contributes to the post-translational modification of proteins such as small GTPases which impacts cell signaling and cytoskeletal organization.
FDPS has a connection to bone diseases such as osteoporosis and also links to cardiovascular disorders. The relationship to osteoporosis arises from its role in bone resorption and osteoclast activity mediated by proteins like RANKL and osteoprotegerin. Cardiovascular disorders may link to altered cholesterol metabolism with FDPS influencing cholesterol biosynthesis and regulation. Inhibition of FDPS activity targets these pathways leading to therapeutic strategies that may address both metabolic and bone health issues.
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Example of standard curve using ab309408. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.
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