Human GNMT ELISA Kit

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GNMT also known as Glycine N-methyltransferase functions by catalyzing the methyl transfer from S-adenosylmethionine (SAM) to glycine which results in the formation of N-methylglycine. This enzyme possesses a molecular mass of approximately 292 amino acids. GNMT expresses strongly in the liver but also occurs in other tissues like the pancreas. It maintains the balance of SAM and influences cellular methylation processes.

Biological function summary

GNMT plays a vital role in regulating the cellular methyl group pool. It lacks association with any complex; instead GNMT works independently to control the levels of SAM influencing numerous methylation reactions. Its activity helps in maintaining normal liver function and detoxification processes within the body. Furthermore GNMT impacts the metabolism of several amino acids.

Pathways

GNMT participates in the methionine cycle and folate metabolism pathways. In the methionine cycle GNMT regulates SAM levels alongside proteins such as methionine adenosyltransferase and S-adenosylhomocysteine hydrolase which influence methylation activities broadly. Through its action within the folate metabolism it connects indirectly with proteins like dihydrofolate reductase contributing to nucleic acid synthesis and cellular growth.

Associated diseases and disorders

GNMT shows a significant association with liver-related diseases and certain cancers. Altered GNMT expression or activity links with liver dysfunction and hepatocellular carcinoma. Additionally in cancer GNMT dysregulation interacts with proteins like tumor suppressor p53 influencing cell proliferation and apoptosis. GNMT's effect on SAM levels affects global DNA methylation impacting gene expression and contributing to disease progression.