Human Anti-Helicobacter pylori IgG ELISA Kit

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Helicobacter pylori IgG often referred to as H. pylori IgG is an immunoglobulin produced in response to infection by the bacterium Helicobacter pylori. This bacterium is known for its spiral shape and Gram-negative characteristics. The molecular weight of the IgG antibody varies but generally is around 150 kDa. It is primarily expressed in response to colonization in the gastric mucosa which leads to increased immune response detectable in the bloodstream. The detection of H. pylori IgG in serological assays helps in diagnosing active or previous H. pylori infections.

Biological function summary

Antibodies such as IgG are part of the immune response working to neutralize pathogens like Helicobacter pylori. H. pylori IgG is not part of a larger protein complex but it interacts directly with antigens on the surface of the bacterial cells. By binding to these antigens H. pylori IgG plays a critical role in opsonization which facilitates the recognition and destruction of the bacteria by immune cells thereby contributing to host defense mechanisms.

Pathways

The H. pylori IgG operates within the broader context of the adaptive immune response pathway. This pathway involves numerous other proteins such as immunoglobulin M (IgM) and T-cell receptors. Together these components coordinate to mount an effective immune response against H. pylori as well as other pathogens. The H. pylori infection triggers a cascade in the immune system that leads to the activation of B cells which produce specific IgG antibodies tailored to recognize the pathogen.

Associated diseases and disorders

Helicobacter pylori infection links closely to chronic gastritis and peptic ulcers. The presence of H. pylori IgG helps clinicians to evaluate such conditions related to gastric mucosal inflammation. These antibodies facilitate the detection of persistent infection contributing to the diagnosis and subsequent treatment strategies. The protein cytokine interleukin-8 (IL-8) also plays an essential role in inflammatory responses during H. pylori infection demonstrating the interconnectedness of immune components in addressing gastric diseases.