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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Human Integrin alpha 2 ELISA kit is a Sandwich (quantitative) ELISA kit for the measurement of Human Integrin alpha 2 in Human in Serum, Plasma, Cell culture supernatant samples.
Colorimetric
Serum, Plasma, Cell culture supernatant
Sandwich (quantitative)
Human
0.102 - 25 ng/mL
= 0.1 ng/mL
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application sELISA | Reactivity Reacts | Dilution info - | Notes - |
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A.(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.
Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, VLA-2 subunit alpha, GPIa, ITGA2, CD49B
Human Integrin alpha 2 ELISA kit is a Sandwich (quantitative) ELISA kit for the measurement of Human Integrin alpha 2 in Human in Serum, Plasma, Cell culture supernatant samples.
Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, VLA-2 subunit alpha, GPIa, ITGA2, CD49B
Colorimetric
Serum, Plasma, Cell culture supernatant
Sandwich (quantitative)
Human
0.102 - 25 ng/mL
Pre-coated microplate (12 x 8 well strips)
= 0.1 ng/mL
Sample type | Average % | Range |
---|---|---|
Sample type Serum | Average % = 120.6 | Range 105 - 131 % |
Sample type Plasma | Average % = 103 | Range 84 - 120 % |
Sample type Cell culture media | Average % = 116.7 | Range 95 - 137 % |
Blue Ice
-20°C
-20°C
Human Integrin alpha 2 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Integrin alpha 2 in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for human Integrin alpha 2 coated on a 96-well plate
Integrin alpha 2 plays a significant role in cellular processes like migration and proliferation. It forms a heterodimer complex by pairing with the beta 1-integrin subunit contributing to its adhesive and signaling functions. This association enables the integrin alpha 2 complex to bind specific extracellular matrix components such as collagen and laminin. Through these interactions it regulates processes like wound healing and tissue remodeling and affects how cells respond to mechanical stress.
Integrin alpha 2 also known as CD49b ITGA2 and A2 is a protein that functions as part of the integrin family. Integrins are transmembrane receptors that facilitate cell-extracellular matrix adhesion. Integrin alpha 2 has a molecular mass of approximately 130 kDa and is widely expressed in epithelial cells fibroblasts and platelets. This protein is important for mediating adhesion between cells and the extracellular matrix affecting cell signaling and behavior. Through this adhesion cells can communicate with their environment adjusting their functions accordingly.
Integrin alpha 2 is involved in major signaling routes that influence cell fate and movement. Notably it participates in the PI3K/AKT and MAPK pathways which are important for regulating cell growth and survival. It interacts with signaling proteins like focal adhesion kinase (FAK) and Src family kinases linking extracellular matrix changes to intracellular responses. These pathways help in transmitting signals that coordinate the cell's structural and functional adjustments in response to its surroundings.
Integrin alpha 2 has connections to cancer and fibrosis. In cancers its altered expression may contribute to tumor progression and metastasis often involving interactions with other integrins and matrix metalloproteinases that degrade extracellular components. In fibrosis excessive integrin alpha 2 activity can lead to abnormal tissue remodeling and scarring implicating its role alongside collagen-producing cells. Understanding these connections is vital for developing therapies targeting integrin-mediated pathways in these diseases.
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Example of standard curve using ab309428. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.
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