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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Human Islet-1 ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human Islet-1 in Human in Serum, Plasma, Cell culture supernatant samples.
Colorimetric
Serum, Plasma, Cell culture supernatant
Sandwich (quantitative)
Human
= 0.1 ng/mL
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application sELISA | Reactivity Reacts | Dilution info - | Notes - |
DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).
Insulin gene enhancer protein ISL-1, Islet-1, ISL1
Human Islet-1 ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human Islet-1 in Human in Serum, Plasma, Cell culture supernatant samples.
Insulin gene enhancer protein ISL-1, Islet-1, ISL1
Colorimetric
Serum, Plasma, Cell culture supernatant
Sandwich (quantitative)
Human
Pre-coated microplate (12 x 8 well strips)
= 0.1 ng/mL
Sample type | Average % | Range |
---|---|---|
Sample type Serum | Average % = 103.1 | Range 98 - 110 % |
Sample type Plasma | Average % = 87.77 | Range 78 - 109 % |
Sample type Cell culture media | Average % = 85.08 | Range 69 - 100 % |
Blue Ice
-20°C
-20°C
Human Islet-1 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Islet-1 in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for human Islet-1 coated on a 96-well plate.
Islet 1 is involved in the differentiation and survival of various cell types. As part of a transcription complex it regulates downstream target genes essential for the development of motor neurons and cardiac muscle. It also contributes significantly to the developmental pathways of insulin-producing beta cells in the pancreas. The ISL1 marker is therefore an important tool for studying cell lineage and fate in developmental biology.
Islet 1 also known as ISL1 is a LIM-homeodomain transcription factor with a molecular mass of approximately 38 kDa. It plays an important role in regulating gene expression during the development of the nervous system and pancreas. You can find Islet 1 predominantly in motor neurons pancreatic beta cells and cardiac muscle cells. Its expression is important during embryonic stages for cell differentiation and maturation. Researchers use "Isl 1 neuronal marker" antibodies to identify this protein's presence in tissue.
Islet 1 is involved in key developmental signaling pathways including the Notch signaling and Wnt signaling pathways. In these pathways Islet 1 collaborates with other proteins like Lhx3 and Ngn2 to ensure proper gene activation for neuronal and cardiac development. Wnt signaling affects the expression of isl 1 marker genes contributing to precise spatial and temporal regulation during embryogenesis.
Islet 1 has links to congenital heart defects and type 2 diabetes. Mutations or altered expression of this protein can disrupt pancreatic beta cell function and motor neuron development. In congenital heart disease the interaction of Islet 1 with proteins like Nkx2.5 is critical. Its role in type 2 diabetes ties with the functioning of other proteins involved in insulin secretion making it a potential target for therapeutic intervention in these conditions.
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Example of standard curve using ab309422. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.
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