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AB313986

Human LRRC4 ELISA Kit

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Human LRRC4 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human LRRC4 in Human in Biofluids, Cell Culture Media samples.

View Alternative Names

BAG, NAG14, UNQ554/PRO1111, LRRC4, Leucine-rich repeat-containing protein 4, Brain tumor-associated protein BAG, Nasopharyngeal carcinoma-associated gene 14 protein, Netrin-G2 ligand, NGL-2

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Sandwich ELISA - Human LRRC4 ELISA Kit (AB313986)
  • sELISA

Supplier Data

Sandwich ELISA - Human LRRC4 ELISA Kit (AB313986)

Example of standard curve using ab313986. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Serum, Plasma, Cell culture supernatant

Reacts with

Human

Assay type

Sandwich (quantitative)

Sensitivity

= 0.42 ng/mL

Range

0.42 - 100 ng/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Human LRRC4 ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human LRRC4 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human LRRC4 coated on a 96-well plate.

This ELISA kit shows no cross-reactivity with the following cytokines tested: human ANGPTL7, CD36, CLEC9a, CL-P1, Dectin-2, DLL4, DSCAM, EDIL3, ENPP-7, Enteropeptidase, FCRL3, FCRLB, FGF-3, FLRT1, FLRT2, GBA3, GDF-11, Glycoprotein V, Granzyme A, IGSF4B, IL-28 R alpha, Kynureninase, LAMA4, LRRTM3, NG2, NQO-1, PCSK2, PILR-alpha, Plexin A4, POGLUT1, PRELP, Smad4, SOX15, SOX7, SOX9, Syntaxin 6, TROP-2, TSLP R, UNC5H4.

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Recovery

[ { "sample": "Serum", "range": "104 - 142 %", "average": "= 116.4" }, { "sample": "Plasma", "range": "102 - 138 %", "average": "= 114.5" }, { "sample": "Cell culture media", "range": "101 - 106 %", "average": "= 103.2" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313986-1x96Tests", "assetComponentDetails": [ { "size":"2 x 1 Vial", "name":"Biotinylated Human LRRC4 Detection Antibody", "number":"AB313986-CMP09", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB313986-CMP05", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313986-CMP04", "productcode":"" }, { "size":"1 x 200 µL", "name":"700X HRP-Streptavidin", "number":"AB313986-CMP03", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313986-CMP06", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313986-CMP07", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human LRRC4 Protein Standard", "number":"AB313986-CMP10", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human LRRC4 Antibody-coated ELISA Plate", "number":"AB313986-CMP08", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Netrin G2 Ligand also known as NGL2 is a synaptic adhesion molecule that weighs approximately 70 kDa. It is predominantly expressed in the central nervous system where it plays an important role in neural development and synaptic function. NGL2 belongs to the family of netrin-G ligands which are known for their involvement in neural network organization. The protein serves as a ligand for netrin-G2 facilitating cell-cell interactions necessary for proper synaptic formation.
Biological function summary

NGL2 contributes significantly to intercellular connectivity by forming part of the synaptic scaffold important for neural communication. It interacts with postsynaptic density proteins leading to stabilization and maturity of synaptic connections. NGL2 functions as a critical component in maintaining synaptic strength and plasticity therefore influencing learning and memory. It operates in conjunction with other synaptic proteins to ensure optimal neurotransmission and signal integration within the brain.

Pathways

NGL2 is intimately involved in the glutamatergic neurotransmission pathway important for synaptic excitability and plasticity. It works together with proteins like SAP102 and PSD-95 which are pivotal in synaptic structure and function. NGL2 also plays a role in the axonal guidance signaling pathway essential for directing neuronal growth and alignment. These pathways integrate the function of NGL2 with broader cellular processes highlighting its significance in neural circuitry.

NGL2 has connections to conditions such as autism spectrum disorders (ASD) and schizophrenia. Dysregulation of NGL2 can lead to aberrant synaptic connections and disruptions in neural communication contributing to the pathogenesis of these disorders. The protein's interaction with neuroligins which are associated with ASD further supports its potential role in disease mechanisms. Understanding NGL2 and its involvement in these diseases opens avenues for therapeutic research targeting synaptic dysfunction.
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Product protocols

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Target data

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).
See full target information LRRC4
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websiteProtocolBooklet
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Product promise

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