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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Human LSECtin ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human LSECtin in Human in Cell culture supernatant, Plasma, Serum samples.
Colorimetric
Cell culture supernatant, Plasma, Serum
Sandwich (quantitative)
Human
0.078 - 20 ng/mL
= 0.078 ng/mL
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application sELISA | Reactivity Reacts | Dilution info - | Notes - |
Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.(Microbial infection) Acts as a receptor for Japanese encephalitis virus.(Microbial infection) Acts as a receptor for Ebolavirus.(Microbial infection) Acts as a receptor for SARS-CoV.(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).
C-type lectin domain family 4 member G, Liver and lymph node sinusoidal endothelial cell C-type lectin, LSECtin, CLEC4G, UNQ431/PRO792
Human LSECtin ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human LSECtin in Human in Cell culture supernatant, Plasma, Serum samples.
C-type lectin domain family 4 member G, Liver and lymph node sinusoidal endothelial cell C-type lectin, LSECtin, CLEC4G, UNQ431/PRO792
Colorimetric
Cell culture supernatant, Plasma, Serum
Sandwich (quantitative)
Human
0.078 - 20 ng/mL
Pre-coated microplate (12 x 8 well strips)
= 0.078 ng/mL
Sample type | Average % | Range |
---|---|---|
Sample type Plasma | Average % = 73.19 | Range 70 - 75 % |
Sample type Serum | Average % = 74.38 | Range 71 - 80 % |
Sample type Cell culture media | Average % = 117.1 | Range 98 - 130 % |
Blue Ice
-20°C
-20°C
Human LSECtin ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human LSECtin in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for human LSECtin coated on a 96-well plate.
LSECtin functions as an important player in immune recognition and clearance of pathogens. It is involved in pathogen binding through interaction with glycans aiding in the modulation of immune responses. LSECtin along with other related receptors like DC-SIGN and CD23 forms part of a complex that influences pathogen recognition. It particularly interacts with viruses like HIV and Ebola impacting how these pathogens are detected and processed by the immune system.
LSECtin also known as CLEC4G is a C-type lectin-like receptor weighing around 40 kDa. It is expressed mainly on liver sinusoidal endothelial cells (LSECs) but also noted in lymph node and placenta tissues. As a receptor LSECtin plays an important role in recognizing and binding to specific glycans on pathogens facilitating their capture and subsequent immune response.
The function of LSECtin integrates into immune system pathways where it influences pathogen clearance. One notable pathway is the pathogen recognition pathway. LSECtin interacts with the liver's immune regulatory network linking with proteins like DC-SIGN that play a role in modulating the immune response. Another pathway it affects is the cell adhesion pathway which involves inflammation regulation.
LSECtin is linked to infections and immune-related liver conditions. In viral infections such as Ebola and HIV LSECtin mediates pathogen capture affecting the body's ability to handle these infections. The receptor's interaction with liver-specific proteins is noted in liver fibrosis where LSECtin and related proteins like CD23 may alter immune function and disease progression. This close relationship highlights the importance of LSECtin in both immune defense and disease pathology.
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Terms & Conditions.
Example of standard curve using ab309401. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.
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