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Human LTBP2 ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human LTBP2 in Human in Serum, Plasma, Cell culture supernatant samples.

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Key facts

Detection method

Colorimetric

Sample types

Serum, Plasma, Cell culture supernatant

Assay type

Sandwich (quantitative)

Reactive species

Human

Range

17.5 - 5000 pg/mL

Sensitivity

= 17.5 pg/mL

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Reactivity data

Application

sELISA

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

May play an integral structural role in elastic-fiber architectural organization and/or assembly.

Alternative names

What's included?

1 x 96 Tests
Components
150X HRP-Streptavidin
1 x 200 µL
20X Wash Buffer
1 x 25 mL
5X Assay Diluent (Item E2)
1 x 15 mL
Biotinylated Human LTBP2 Detection Antibody
2 x 1 Vial
Human LTBP2 Antibody-coated ELISA Plate
1 x 1 Unit
Lyophilized Human LTBP2 Protein Standard
2 x 1 Vial
Stop Solution; 0.2M Sulfuric Acid
1 x 8 mL
TMB One-Step Substrate Reagent
1 x 12 mL

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Human LTBP2 ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human LTBP2 in Human in Serum, Plasma, Cell culture supernatant samples.

Alternative names

Key facts

Detection method

Colorimetric

Sample types

Serum, Plasma, Cell culture supernatant

Assay type

Sandwich (quantitative)

Reactive species

Human

Range

17.5 - 5000 pg/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

Sensitivity

= 17.5 pg/mL

Recovery

Sample specific recovery

Sample type

Serum

Average %

= 112.5

Range

101 - 123 %

Sample type

Plasma

Average %

= 107.3

Range

98 - 120 %

Sample type

Cell culture media

Average %

= 100.4

Range

93 - 105 %

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Storage information

-20°C

Notes

Human LTBP2 ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human LTBP2 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human LTBP2 coated on a 96-well plate.

Supplementary info

Biological summary

LTBP2 interacts with the extracellular matrix components and acts as a structural protein. LTBP2 is an important part of TGF-β complexes. By anchoring TGF-β in a latent form it controls the availability and activation of TGF-β which is necessary for processes like cell growth differentiation and tissue repair. Without LTBP2 the controlled release of TGF-β can be disrupted impacting various cell functions.

Mechanical summary

LTBP2 also known as latent transforming growth factor-beta binding protein 2 is a glycoprotein involved in the regulation of transforming growth factor-beta (TGF-β) signaling. This protein has a mass of approximately 195 kDa. LTBP2 is expressed in a variety of tissues including the lungs heart and eyes. It plays an important role in the extracellular matrix where it is fundamental to the sequestration and subsequent activation of TGF-β.

Pathway

LTBP2 regulates the TGF-β signaling pathway and maintains its equilibrium. This regulatory function links LTBP2 to the pathways involving cell proliferation and differentiation. LTBP2 closely interacts with other members of the LTBP family as well as proteins like fibrillin which are involved in the structural integrity of the extracellular matrix. These interactions are significant for maintaining proper signal transduction and cellular responses.

Disease

LTBP2 mutations have associations with conditions such as glaucoma and Weill-Marchesani syndrome. In glaucoma abnormalities in LTBP2 might affect the integrity of the extracellular matrix influencing intraocular pressure regulation. It also connects to fibrillin-related disorders due to its interaction with fibrillin proteins. These associations highlight the importance of LTBP2 in both structural and signaling roles within the body.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Sandwich ELISA - Human LTBP2 ELISA Kit (ab313988), expandable thumbnail

    Sandwich ELISA - Human LTBP2 ELISA Kit (ab313988)

    Example of standard curve using ab313988. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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