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AB313913

Human NRXN3 ELISA Kit

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Human NRXN3 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human NRXN3 in Human in Cell Culture Media, Biofluids samples.

View Alternative Names

KIAA0743, NRXN3, Neurexin-3-beta, Neurexin III-beta

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Sandwich ELISA - Human NRXN3 ELISA Kit (AB313913)
  • sELISA

Supplier Data

Sandwich ELISA - Human NRXN3 ELISA Kit (AB313913)

Example of standard curve using ab313913. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Cell culture supernatant, Plasma, Serum

Reacts with

Human

Assay type

Sandwich (quantitative)

Sensitivity

= 0.48 ng/mL

Range

0.48 - 32 ng/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Human NRXN3 beta ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human NRXN3 beta in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human NRXN3 beta coated on a 96-well plate.

This ELISA kit shows no cross-reactivity with the following cytokines tested: human 4-1BB Ligand (TNFSF9), Activin RIIB, Aminopeptidase P2 (XPNPEP2), BAMBI (NMA), BOC, Brevican, Carbonic Anhydrase XII, Carboxypeptidase A2, CD300c (LMIR2), CD320 (TCblR, 8D6A), CDNF, CDO, CHST1, CHST4, CILP1, CNTF R alpha, CRIM1, CRTAC1, CXADR, Dopa Decarboxylase (DDC), DPPII (QPP, DPP7), DSPG3, EMR2, FCAR (CD89), FCRL1 (FcRH1), FCRL2 (FcRH2), Gas6, GPR56, GPVI, Hepsin, ILT2 (CD85j), Jagged 2, Kirrel3 (NEPH2), KLF4, LAIR1, LAMP, LAMP1 (CD107a), MDGA1, MIS RII.

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Recovery

[ { "sample": "Serum", "range": "105 - 137 %", "average": "= 115.3" }, { "sample": "Plasma", "range": "91 - 120 %", "average": "= 105.5" }, { "sample": "Cell culture media", "range": "81 - 117 %", "average": "= 103.2" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313913-1x96Tests", "assetComponentDetails": [ { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313913-CMP04", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human NRXN3 Antibody-coated ELISA Plate", "number":"AB313913-CMP08", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human NRXN3 Detection Antibody", "number":"AB313913-CMP09", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313913-CMP07", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313913-CMP06", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human NRXN3 Protein Standard", "number":"AB313913-CMP10", "productcode":"" }, { "size":"1 x 200 µL", "name":"200X HRP-Streptavidin", "number":"AB313913-CMP03", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB313913-CMP05", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurexin 3 also known as NRXN3 is a member of the neurexin family of synaptic cell adhesion molecules. It weighs approximately 160 kDa. It is expressed widely in the brain where it plays a critical role in the connection between neurons. The NRXN3 protein helps establish and maintain synaptic connections facilitating communication in the nervous system. Different isoforms of NRXN3 generated through alternative splicing allow for diverse synaptic functions.
Biological function summary

The protein contributes to the formation of complex structures in synapses. NRXN3 interacts with neuroligins and other postsynaptic proteins forming a bridge across the synaptic cleft. This interaction is essential for the alignment and stabilization of pre- and postsynaptic formations influencing synaptic transmission. The NRXN3 complex enables specific synaptic architecture affecting both excitatory and inhibitory synapses.

Pathways

NRXN3 plays a role in key neural signaling routes. It participates in the synaptic formation and plasticity pathways being important for both synaptogenesis and synaptic maintenance. NRXN3 shares pathway interactions with proteins such as neuroligin and dystroglycan. This alignment is important for regulating synapse stabilization and may influence the release of neurotransmitters across synaptic junctions.

NRXN3 is linked to neurological conditions including autism spectrum disorders (ASD) and schizophrenia. Genetic variations in NRXN3 have been associated with synaptic dysfunction that can contribute to these conditions. It connects with proteins such as NRXN1 and neuroligins which are also implicated in similar neuropsychiatric disorders. Understanding NRXN3's involvement could aid in developing targeted therapies for these complex diseases.
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Product protocols

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Target data

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response (By similarity).
See full target information NRXN3
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websiteProtocolBooklet
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Complementary Products

Primary Antibodies

AB192313

Anti-NRXN3 antibody

Western blot - Anti-NRXN3 antibody (AB192313)

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Proteins & Peptides

AB276438

Recombinant Human NRXN3 protein (His tag)

SDS-PAGE - Recombinant Human NRXN3 protein (His tag) (AB276438)

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