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AB313914

Human Oligodendrocyte myelin glycoprotein ELISA Kit

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Human Oligodendrocyte myelin glycoprotein ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Oligodendrocyte myelin glycoprotein in Human in Cell Culture Media, Biofluids samples.

View Alternative Names

OMGP, OMG, Oligodendrocyte-myelin glycoprotein

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Sandwich ELISA - Human Oligodendrocyte myelin glycoprotein ELISA Kit (AB313914)
  • sELISA

Supplier Data

Sandwich ELISA - Human Oligodendrocyte myelin glycoprotein ELISA Kit (AB313914)

Example of standard curve using ab313914. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Cell culture supernatant, Plasma, Serum

Reacts with

Human

Assay type

Sandwich (quantitative)

Sensitivity

= 0.39 ng/mL

Range

0.391 - 25 ng/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Human Oligodendrocyte myelin glycoprotein ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Oligodendrocyte myelin glycoprotein in serum, plasma (collect plasma using EDTA and Citrate as an anticoagulant. Heparin is not recommended in this assay), and cell culture supernatants. This assay employs an antibody specific for human Oligodendrocyte myelin glycoprotein coated on a 96-well plate.
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Recovery

[ { "sample": "Serum", "range": "68 - 80 %", "average": "= 73.66" }, { "sample": "Plasma", "range": "68 - 76 %", "average": "= 72.23" }, { "sample": "Cell culture media", "range": "68 - 88 %", "average": "= 77.73" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313914-1x96Tests", "assetComponentDetails": [ { "size":"1 x 200 µL", "name":"200X HRP-Streptavidin", "number":"AB313914-CMP03", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313914-CMP07", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human Oligodendrocyte myelin glycoprotein Antibody-coated ELISA Plate", "number":"AB313914-CMP08", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human Oligodendrocyte myelin glycoprotein Protein Standard", "number":"AB313914-CMP10", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB313914-CMP05", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313914-CMP04", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human Oligodendrocyte myelin glycoprotein Detection Antibody", "number":"AB313914-CMP09", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313914-CMP06", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Oligodendrocyte myelin glycoprotein (OMGP) also known as oligodendrocyte myelin marker has a molecular weight of approximately 50 kDa. It is a glycoprotein primarily found in the myelin of the central nervous system (CNS) notably in the white matter. OMGP appears as an element on the surface of oligodendrocytes and contributes significantly to the stability and function of the myelin sheath.
Biological function summary

OMGP plays an essential role in the CNS where it interacts with other structural components to maintain myelin integrity. OMGP is not a component of a larger complex but works closely with other myelin proteins such as myelin basic protein. It also inhibits neurite outgrowth helping regulate neural plasticity and potentially preventing improper nerve regeneration in mature central nervous systems.

Pathways

Research recognized OMGP as a contributor in the Nogo receptor (NgR) signaling pathway influencing the inhibition of axonal growth. Within this pathway OMGP associates with other proteins like Nogo-A and the receptor NgR1 regulating neuronal growth by binding to these proteins and suppressing neurite outgrowth. This interaction is important in maintaining the structural arrangement of the CNS and modulating its repair mechanisms.

OMGP has connections with multiple sclerosis (MS) and some neurodegenerative diseases. In MS changes in OMGP expression correlate with demyelination and faulty nerve function. Moreover OMGP interrelates with Nogo-A another protein present in damaged myelin which may influence disease progression by hindering nerve repair. ALS (Amyotrophic Lateral Sclerosis) research also considers OMGP's role in neurodegeneration suggesting a broader impact on CNS pathologies.
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Product protocols

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Target data

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
See full target information OMG
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websiteProtocolBooklet
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