Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Product Insider Program
Be the first to know about our latest product launches - and unlock exclusive offers and discounts.
Human PCOLCE ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human PCOLCE in Human in Cell culture supernatant, Plasma, Serum samples.
Colorimetric
Cell culture supernatant, Plasma, Serum
Sandwich (quantitative)
Human
51 - 12500 pg/mL
= 51 pg/mL
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application sELISA | Reactivity Reacts | Dilution info - | Notes - |
Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
Procollagen C-endopeptidase enhancer 1, Procollagen COOH-terminal proteinase enhancer 1, Type 1 procollagen C-proteinase enhancer protein, Type I procollagen COOH-terminal proteinase enhancer, PCPE-1, Procollagen C-proteinase enhancer 1, PCPE1, PCOLCE
Human PCOLCE ELISA Kit is a Sandwich (quantitative) ELISA kit for the measurement of Human PCOLCE in Human in Cell culture supernatant, Plasma, Serum samples.
Procollagen C-endopeptidase enhancer 1, Procollagen COOH-terminal proteinase enhancer 1, Type 1 procollagen C-proteinase enhancer protein, Type I procollagen COOH-terminal proteinase enhancer, PCPE-1, Procollagen C-proteinase enhancer 1, PCPE1, PCOLCE
Colorimetric
Cell culture supernatant, Plasma, Serum
Sandwich (quantitative)
Human
51 - 12500 pg/mL
Pre-coated microplate (12 x 8 well strips)
= 51 pg/mL
Sample type | Average % | Range |
---|---|---|
Sample type Serum | Average % = 122.3 | Range 108 - 137 % |
Sample type Plasma | Average % = 109.8 | Range 93 - 118 % |
Sample type Cell culture media | Average % = 130 | Range 116 - 141 % |
Blue Ice
-20°C
-20°C
Human PCOLCE ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human PCOLCE in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human PCOLCE coated on a 96-well plate.
PCOLCE serves as an enhancer of enzyme activity important for proper collagen maturation. This protein strongly associates with the biosynthesis of collagen fibrils being part of the larger complex responsible for proper collagen assembly. The effective regulation of collagen fibrils is essential for maintaining structural integrity and strength of various tissues such as the skin and bone matrix.
PCOLCE known as Procollagen C-endopeptidase enhancer is a glycoprotein with an approximate mass of 55 kDa. It resides mainly in the extracellular matrix playing a role in collagen processing. PCOLCE enhances the activity of the enzyme procollagen C-proteinase which is critical for converting procollagen to collagen by cleaving its C-terminal propeptide. PCOLCE expression occurs in tissues such as skin tendons and cartilage where collagen is abundant.
PCOLCE plays an important role in the collagen biosynthesis and modifying pathways. It collaborates closely with other proteins like BMP1 (Bone Morphogenetic Protein 1) which also participates in the procollagen processing activity. Through its precise regulation PCOLCE affects tissue repair and development pathways ensuring efficient collagen synthesis and deposition critical for functional extracellular matrix formation.
Mutations or dysregulation in PCOLCE can potentially relate to connective tissue disorders such as Ehlers-Danlos syndrome. In these conditions improper collagen processing occurs affecting tissue elasticity and strength. Studies suggest that abnormal PCOLCE activity may also influence fibrosis where excessive collagen deposition leads to tissue and organ dysfunction. In these contexts PCOLCE interaction with proteins like BMP1 and other collagen-modifying enzymes is significant affecting the progression of such disorders.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Example of standard curve using ab313921. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com