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AB108670

Human Progesterone ELISA Kit

5

(1 Review)

|

(14 Publications)

Human Progesterone ELISA Kit is a competitive ELISA designed to quantify Human Progesterone with a sensitivity of 0.05 ng/mL

- Colorimetric competitive ELISA - 450 nm readout - works on any plate reader
- Wide dynamic range - quantifies 0.2 - 40 ng/ml
- Cited in over 10 publications

View Alternative Names

Pregn 4 ene 3 20 dione

1 Images
ELISA - Human Progesterone ELISA Kit (AB108670)
  • ELISA

Unknown

ELISA - Human Progesterone ELISA Kit (AB108670)

Representative Standard Curve using ab108670.

Key facts

Detection method

Colorimetric

Sample types

Citrate plasma, EDTA Plasma, Heparin Plasma, Serum

Reacts with

Human

Assay type

Competitive

Sensitivity

= 0.05 ng/mL

Range

0.2 - 40 ng/mL

Assay Platform

Microplate

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "cELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Abcam's Progesterone in vitro competitive ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate quantitative measurement of Progesterone in serum and plasma.

A 96-well plate has been precoated with anti-Progesterone. Samples and the Progesterone-HRP conjugate are added to the wells, where Progesterone in the sample competes with the added Progesterone-HRP for antibody binding. After incubation, the wells are washed to remove unbound material and TMB substrate is then added which is catalyzed by HRP to produce blue coloration. The reaction is terminated by addition of Stop Solution which stops the color development and produces a color change from blue to yellow. The intensity of signal is inversely proportional to the amount of Progesterone in the sample and the intensity is measured at 450 nm.

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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab108670-1x96Tests", "assetComponentDetails": [ { "size":"1 x 15 mL", "name":"Stop Solution", "number":"AB108670-CMP12", "productcode":"" }, { "size":"1 x 1 mL", "name":"Progesterone control", "number":"AB108670-CMP13", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Strip holder", "number":"AB108670-CMP03", "productcode":"" }, { "size":"1 x 1 mL", "name":"Progesterone Standard 2 - 1.0 ng/mL", "number":"AB108670-CMP08", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Anti-Progesterone IgG Coated Wells", "number":"AB108670-CMP01", "productcode":"" }, { "size":"1 x 15 mL", "name":"TMB Substrate Solution", "number":"AB108670-CMP04", "productcode":"" }, { "size":"1 x 22 mL", "name":"Progesterone-HRP Conjugate", "number":"AB108670-CMP05", "productcode":"" }, { "size":"1 x 1 mL", "name":"Progesterone Standard 0 - 0 ng/mL", "number":"AB108670-CMP06", "productcode":"" }, { "size":"1 x 50 mL", "name":"10X Wash Solution", "number":"AB108670-CMP11", "productcode":"" }, { "size":"1 x 1 mL", "name":"Progesterone Standard 1 - 0.2 ng/mL", "number":"AB108670-CMP07", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Cover foils", "number":"AB108670-CMP02", "productcode":"" }, { "size":"1 x 1 mL", "name":"Progesterone Standard 3 - 5.0 ng/mL", "number":"AB108670-CMP14", "productcode":"" }, { "size":"1 x 1 mL", "name":"Progesterone Standard 4 - 15.0 ng/mL", "number":"AB108670-CMP15", "productcode":"" }, { "size":"1 x 1 mL", "name":"Progesterone Standard 5 - 40.0 ng/mL", "number":"AB108670-CMP16", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Progesterone also called P4 is a steroid hormone playing an important role in the reproductive system. Its molecular weight is approximately 314.47 Da. This hormone is mainly expressed in the ovaries but also in the adrenal glands and placenta. Progesterone acts by binding to its receptor the progesterone receptor (PR) which is found in target tissues such as the uterus mammary glands and the brain. When progesterone binds to PR it translocates to the nucleus to act as a transcription factor regulating gene expression that is important for reproductive function.
Biological function summary

Progesterone is essential for preparation and maintenance of pregnancy. It facilitates the transformation of the endometrium to a secretory phase to support embryo implantation. It also modulates immune responses during pregnancy to prevent the maternal immune system from rejecting the fetus. Progesterone and its receptor are not part of a larger protein complex but they do interact with other molecular pathways to exert their actions. Additionally progesterone inhibits the proliferation of mammary gland epithelial cells contributing to breast development and function.

Pathways

Progesterone plays a significant role in the menstrual cycle and pregnancy-related pathways. It works within the ovarian steroidogenesis pathway which includes other hormones like estrogen and luteinizing hormone. This pathway ensures the release and regulation of female sex hormones. Progesterone also interacts with the MAPK signaling pathway which involves proteins such as ERK1/2 affecting cellular processes including cell growth and differentiation.

Progesterone is linked to conditions such as endometriosis and breast cancer. In endometriosis progesterone resistance leads to the abnormal growth of endometrial tissue outside the uterus. The hormone's association with breast cancer involves its interaction with proteins like estrogen receptor alpha which can promote cancer cell proliferation when dysregulated. Understanding progesterone’s role in disease helps in developing therapeutic strategies to manage these conditions.
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Product protocols

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Target data

See full target information Progesterone
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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 16:6130-6139 PubMed39544804

2024

Analysis of independent risk factors for postpartum depression in elderly primiparas and the effects of mindfulness-based psychological intervention.

Applications

Unspecified application

Species

Unspecified reactive species

Baihong Wu,Nan Wang,Lili Hu,Guohe Wu

American journal of translational research 16:4216-4224 PubMed39262738

2024

Comparison of the efficacy of phloroglucinol versus ritodrine hydrochloride in preventing miscarriage and adverse reactions.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wang,Bo Liu,Ting Tian,Xiaocai Zhang,Bei Chen,Min Wang,Yuanfeng Gou,Libin Lian

Pathophysiology : the official journal of the International Society for Pathophysiology 31:408-419 PubMed39189167

2024

Ink Mitigates Dehydroepiandrosterone-Induced Insulin Resistance in Mouse Model of Polycystic Ovarian Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Prathyusha Yamarthi,Rama Satyasri Kotipalli,Samatasai Patnaik,Kv Veena,Muralidharan Kathirvel,Rajkumar Vutukuri,Manjula Bhanoori

Metabolites 13: PubMed37512583

2023

Trimethylamine N-Oxide Concentration and Blood Pressure in Young Healthy Men and Women: A Replicated Crossover Study.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha N Rowland,Liam M Heaney,Mariasole Da Boit,Stephen J Bailey

Frontiers in endocrinology 13:1000094 PubMed36387874

2022

Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?

Applications

Unspecified application

Species

Unspecified reactive species

Pamela A Nono Nankam,Manuel Cornely,Nora Klöting,Matthias Blüher

Stem cell research & therapy 13:474 PubMed36104746

2022

Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaojiao Cheng,Xiangyan Ruan,Yanglu Li,Juan Du,Fengyu Jin,Muqing Gu,Qi Zhou,Xin Xu,Yu Yang,Husheng Wang,Alfred Otto Mueck

Experimental and therapeutic medicine 19:1855-1863 PubMed32104241

2020

Expression of SUMO associated proteins in the mouse endometrium is regulated by ovarian hormones throughout the estrous cycle.

Applications

ELISA

Species

Unspecified reactive species

Yi Liu,Xiaofang Ma,Xuhong Chen,Jinsheng Chen,Li Yuan,Lili Li,Yaowu Bai,Xiaozhi Liu

Scientific reports 9:8367 PubMed31182728

2019

Progesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zejun Zhou,Chuanxiu Bian,Zhenwu Luo,Constance Guille,Elizabeth Ogunrinde,Jiapeng Wu,Min Zhao,Sylvia Fitting,Diane L Kamen,Jim C Oates,Gary Gilkeson,Wei Jiang

The Journal of clinical endocrinology and metabolism 104:1005-1019 PubMed30445606

2018

Differences in First-Trimester Maternal Metabolomic Profiles in Pregnancies Conceived From Fertility Treatments.

Applications

Unspecified application

Species

Unspecified reactive species

Tianyanxin Sun,Bora Lee,Jason Kinchen,Erica T Wang,Tania L Gonzalez,Jessica L Chan,Jerome I Rotter,Yii-Der Ida Chen,Kent Taylor,Mark O Goodarzi,Stephen S Rich,Charles R Farber,John Williams,Margareta D Pisarska

Journal of reproductive immunology 127:16-18 PubMed29656181

2018

Elevated systemic microbial translocation in pregnant HIV-infected women compared to HIV-uninfected women, and its inverse correlations with plasma progesterone levels.

Applications

Unspecified application

Species

Unspecified reactive species

Zejun Zhou,Anna Maya Powell,Vishwanathan Ramakrishnan,Allison Eckard,Carol Wagner,Wei Jiang
View all publications
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