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AB108769

Human Anti-Schistosoma mansoni IgG ELISA Kit

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(1 Publication)

Human Anti-Schistosoma mansoni IgG ELISA Kit is an indirect ELISA for the qualitative detection of IgG class antibodies against Schistosoma mansoni in human plasma and serum samples.

- Colorimetric readout - 450 nm - Works on any standard plate reader
- Easy results interpretation
- Cut-off, positive and negative controls included

Key facts

Detection method

Colorimetric

Sample types

Citrate plasma, Heparin Plasma, Serum

Reacts with

Human

Assay type

Indirect

Assay Platform

Microplate

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Abcam's anti-Schistosoma mansoni IgG Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate qualitative measurement of IgG class antibodies against Schistosoma mansoni in Human serum and plasma.

A 96-well plate has been precoated with Schistosoma mansoni antigens to bind cognate antibodies. Controls or test samples are added to the wells and incubated. Following washing, a horseradish peroxidise (HRP) labelled Protein A conjugate is added to the wells, which binds to the immobilized Schistosoma mansoni-specific antibodies. TMB is then catalyzed by the HRP to produce a blue color product that changes to yellow after adding an acidic stop solution. The density of yellow coloration is directly proportional to the amount of Schistosoma mansoni IgG sample captured in plate.

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

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Precision

[ { "reproducibilityType": "Inter", "sample": "Serum", "replicates": 4, "mean": null, "standardDeviation": null, "coefficientOfVariability": "5.7" }, { "reproducibilityType": "Intra", "sample": "Serum", "replicates": 24, "mean": null, "standardDeviation": null, "coefficientOfVariability": "5.1" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab108769-1x96Tests", "assetComponentDetails": [ { "size":"1 x 2 mL", "name":"Schistosoma mansoni IgG Negative Control", "number":"AB108769-CMP05", "productcode":"" }, { "size":"1 x 3 mL", "name":"Schistosoma mansoni IgG Cut-off Control", "number":"AB108769-CMP04", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Strip holder", "number":"AB108769-CMP06", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Schistosoma mansoni (IgG) Coated Microplate (12 x 8 wells)", "number":"AB108769-CMP02", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Cover foil", "number":"AB108769-CMP07", "productcode":"" }, { "size":"1 x 15 mL", "name":"TMB Substrate Solution", "number":"AB108769-CMP08", "productcode":"" }, { "size":"1 x 50 mL", "name":"20X Washing Solution", "number":"AB108769-CMP10", "productcode":"" }, { "size":"1 x 2 mL", "name":"Schistosoma mansoni IgG Positive Control", "number":"AB108769-CMP03", "productcode":"" }, { "size":"1 x 100 mL", "name":"IgG Sample Diluent", "number":"AB108769-CMP01", "productcode":"" }, { "size":"1 x 15 mL", "name":"Stop Solution", "number":"AB108769-CMP11", "productcode":"" }, { "size":"1 x 20 mL", "name":"Protein A HRP Conjugate", "number":"AB108769-CMP09", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Schistosoma mansoni IgG also known as anti-Schistosoma IgG is an immunoglobulin targeting the parasite Schistosoma mansoni. This antibody plays a significant role in the immune response against the parasitic infection. The molecular mass of IgG generally ranges around 150 kDa. It is primarily expressed in the blood by B cells as part of the immune system response to parasitic infections. Detection of Schistosoma mansoni IgG is often utilized in diagnostic tests providing insights into exposure and immune response levels.
Biological function summary

This immunoglobulin facilitates the recognition and neutralization of the Schistosoma mansoni parasite. It does not form part of large protein complexes but interacts intricately with antigen-binding regions. Upon binding IgG initiates a cascade of immune responses including opsonization which marks the parasite for destruction by other immune cells. This antibody functions as an important component in targeting and managing parasitic infection through its specific affinity for schistosome antigens.

Pathways

Schistosoma mansoni IgG plays a pivotal role in the adaptive immune response against parasitic infections. It is integral to the antibody-mediated immune pathways including the complement activation pathway and antibody-dependent cellular cytotoxicity. These pathways involve other proteins such as complement proteins which enhance the ability of antibodies to clear pathogens. IgG's involvement assists in neutralizing the parasite and mitigating the infection's impact.

Schistosoma mansoni IgG is directly related to schistosomiasis also known as bilharzia. The presence and levels of this antibody in serum serve as indicators of exposure and an ongoing immune response to Schistosoma mansoni infection. Its detection is important for diagnosing schistosomiasis. Additionally proteins such as the parasite's antigens play a role in the disease process interacting with IgG to trigger an immune response that helps control the infection.
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Product protocols

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Target data

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 38:110611 PubMed35354052

2022

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans.

Applications

Unspecified application

Species

Unspecified reactive species

Isabella Huettner,Stefanie A Krumm,Sonia Serna,Katarzyna Brzezicka,Serena Monaco,Samuel Walpole,Angela van Diepen,Fiona Allan,Thomas Hicks,Simon Kimuda,Aidan M Emery,Elise Landais,Cornelis H Hokke,Jesus Angulo,Niels Reichardt,Katie J Doores
View all publications
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websiteProtocolBooklet
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