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AB314349

Human Slitrk ELISA Kit

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Human Slitrk ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Slitrk in Human in Cell Culture Media, Biofluids samples.

View Alternative Names

KIAA1910, LRRC12, UNQ233/PRO266, SLITRK1, SLIT and NTRK-like protein 1, Leucine-rich repeat-containing protein 12

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Sandwich ELISA - Human Slitrk ELISA Kit (AB314349)
  • sELISA

Supplier Data

Sandwich ELISA - Human Slitrk ELISA Kit (AB314349)

Example of standard curve using ab314349. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Cell culture supernatant, Plasma, Serum

Reacts with

Human

Assay type

Sandwich (quantitative)

Sensitivity

= 0.74 ng/mL

Range

0.74 - 200 ng/mL

Assay Platform

Pre-coated microplate (12 x 8 well strips)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Human Slitrk ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Slitrk in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human Slitrk coated on a 96-well plate.
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Recovery

[ { "sample": "Serum", "range": "77 - 134 %", "average": "= 103.1" }, { "sample": "Plasma", "range": "71 - 95 %", "average": "= 82.16" }, { "sample": "Cell culture media", "range": "83 - 127 %", "average": "= 103" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab314349-1x96Tests", "assetComponentDetails": [ { "size":"2 x 1 Vial", "name":"Lyophilized Human Slitrk Protein Standard", "number":"AB314349-CMP10", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB314349-CMP05", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB314349-CMP07", "productcode":"" }, { "size":"1 x 200 µL", "name":"100X HRP-Streptavidin", "number":"AB314349-CMP03", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB314349-CMP06", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human Slitrk Antibody-coated ELISA Plate", "number":"AB314349-CMP08", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB314349-CMP04", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human Slitrk Detection Antibody", "number":"AB314349-CMP09", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Slitrk1 also known as SLIT and NTRK-like protein 1 is a transmembrane protein with a mass of approximately 95 kDa. It functions mechanically by interacting with neuronal cells to influence axonogenesis and synaptogenesis. Slitrk1 has a role in the nervous system where it is primarily expressed particularly in the brain. Its structure includes leucine-rich repeat (LRR) domains facilitating its interactions with the cellular environment and other molecules.
Biological function summary

Slitrk1 influences neural development and synapse formation playing a role in the regulation of synaptic strength. It may interact with the receptor protein tyrosine phosphatase sigma (PTPσ) forming a receptor-ligand pair critical for its function in neural contexts. This interaction contributes to promoting proper neuronal connections and maintaining synaptic plasticity which is essential for cognitive processes.

Pathways

The role Slitrk1 plays in neural development connects it to the neurotrophic signaling pathway. This pathway influences neuron survival development and function. Slitrk1 is also linked with the semaphorin-plexin signaling pathway which guides axon guidance and neuronal positioning. Proteins like neurotrophin receptor TrkC and plexins may relate to Slitrk1 within these pathways influencing its downstream signaling effects.

Genetic mutations in Slitrk1 have been associated with Tourette syndrome and trichotillomania. These conditions are neurodevelopmental indicating Slitrk1’s importance in the nervous system's proper function. Slitrk1's association with PTPσ in these disorders shows its potential as a therapeutic target as PTPσ's pathway disruption could contribute to the symptoms observed in these disorders.
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Product protocols

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Target data

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed : 27273464, PubMed : 27812321). Enhances neuronal dendrite outgrowth (PubMed : 16224024, PubMed : 19640509).
See full target information SLITRK1
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Complementary Products

Primary Antibodies

AB67238

Anti-Slitrk1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slitrk1 antibody (AB67238)

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Proteins & Peptides

AB276254

Recombinant Human Slitrk1 protein (Fc Chimera His Tag)

SDS-PAGE - Recombinant Human Slitrk1 protein (Fc Chimera His Tag) (AB276254)

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Product promise

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